The rationale of scored tablets as dosage form
The rationale of scored tablets as dosage form
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DOI：
10.1016/j.ejps.2003.10.018
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发表时间：
2004-02-01
影响因子：
4.6
通讯作者：
Barends, DM
中科院分区：
文献类型：
--
作者：
Rodenhuis, N;De Smet, PAGM;Barends, DM
本研究的目的是深入了解刻痕片剂的原理。通过研究患者细分（“破碎”）有刻痕和无刻痕片剂的原因来进行。询问了在荷兰5个社区药房领取处方的患者。研究了275个处方。在所有分发的片剂中，31%被细分，主要是因为处方需要细分的剂量。然而，有30%是根据患者自己的主动性进行细分的：13%是为了便于吞咽，17%是因为患者选择服用较低剂量。即使是未刻痕的片剂也被细分：因为处方剂量是片剂剂量的一半（6%），便于吞咽（1%）和患者希望服用较低剂量（3%）。还询问了患者对刻痕片剂易于细分的看法。在55%的病例中报告了刻痕片剂的问题细分，其中42%归因于功能障碍的刻痕线。我们还研究了处方和分发其他药品作为需要细分的片剂替代品的可能性。对于46%的患者，市场上有较低剂量的剂型，对于54%的患者，没有。我们得出结论，刻痕片剂仍然发挥着重要作用。即使当较低剂量的片剂变得可用时，患者仍然非常希望细分片剂以便于吞咽和调整剂量。改善刻痕线的功能可能是比禁止这种剂型更实际的方法。(C)2003 Elsevier B.V.保留所有权利。
The aim of the study was to get insight into the rationale of scored tablets. This was pursued by studying patient's reasons for subdividing ("breaking") scored and unscored tablets. Patients who picked up their prescriptions in 5 community pharmacies in The Netherlands were questioned. Two-hundred and seventy-five prescriptions were studied. Of all dispensed tablets, 31% were subdivided, mostly because a dose that needed subdivision was prescribed. However, 30% were subdivided upon the initiative of the patient himself: 13% for ease of swallowing and 17% because the patient chose to take a lower dose. Even unscored tablets were subdivided: because the dose prescribed was half the tablet dose (6%), for ease of swallowing (1%) and the wish of the patient to take a lower dose (3%). It was also inquired about the patient's perception of the ease of subdivision of scored tablets. Problematic subdivision of scored tablets was reported in 55% of the cases, 42% of which was attributed to a disfunctioning score line. We also studied the possibility to prescribe and dispense other medicinal products as alternatives for tablets that needed to be subdivided. For 46% a dosage form with a lower dose was on the market, for 54% it was not. We conclude that scored tablets still fulfil an important role. Even when lower dosed tablets would become available, there remains a substantial wish of patients to subdivide tablets for ease of swallowing and adapting the dose. Improving the functioning of score lines may be a more practical approach than banning this dosage form. (C) 2003 Elsevier B.V. All rights reserved.