ETIOLOGICAL IMPLICATION OF MATERNAL AGE AND BIRTH-ORDER IN INFANTILE-AUTISM
ETIOLOGICAL IMPLICATION OF MATERNAL AGE AND BIRTH-ORDER IN INFANTILE-AUTISM
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DOI：
10.1007/bf01531359
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发表时间：
1983-01-01
影响因子：
3.9
通讯作者：
STEWART, MA
中科院分区：
文献类型：
--
作者：
TSAI, LY;STEWART, MA
将113例自闭症患者的出生顺序和母亲年龄与一般人群进行比较。在自闭症组中，年龄在35岁或以上的母亲数量过多，尽管整个组中母亲的平均年龄与一般人群非常相似。自闭症患者的出生顺序偏离平均水平。与基础人群相比，更多的自闭症患者是高危妊娠（定义为第一胎、第四胎或更晚出生，或母亲年龄在30岁或以上）的产物。至少有一些环境因素显然与自闭症的成因有关。多因素机制可能是部分或全部病例的原因。
Birth orders and maternal ages of the 113 autistic patients were compared with those of the general population. An excess of mothers aged 35 or older was observed in the autistic group, though the mean maternal age for the whole group was very similar to those of the general population. A deviation from average in birth order was observed in autistics. Significantly more autistics were products of at-risk pregnancies (defined as either 1st, 4th, or later born, or born to mothers aged 30 yr or older) than the base population. At least some environmental factors are apparently involved in the causation of autism. A multifactorial mechanism may be responsible for some or all of the cases.