Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria
Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria
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DOI：
10.1016/s1096-7192(03)00047-7
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发表时间：
2003-04-01
影响因子：
3.8
通讯作者：
Ware, RE
中科院分区：
文献类型：
--
作者：
Heeney, MM;Ormsbee, SM;Ware, RE
PNH和相关血液学疾病（再生障碍性贫血、骨髓增生异常综合征）患者的中性粒细胞对细胞凋亡的抵抗已被描述，但其分子基础尚不清楚。通过基因表达分析，与正常对照组相比，PNH粒细胞相对过表达四种抗凋亡基因（人A1、hHR23B、Mcl-1和RhoA）。这些发现被RT-PCR分析证实，并在PNH患者的外周血粒细胞和单核细胞中观察到。抗凋亡基因上调可能在PNH和相关疾病中赋予细胞凋亡抗性，并在骨髓损伤后提供一种共同的代偿机制，允许剩余的造血干细胞存活和生长。(C) 2003 Elsevier Science（美国）版权所有。
Resistance to apoptosis has been described in neutrophils from patients with PNH and related hematologic disorders (aplastic anemia, myelodysplastic syndrome), but its molecular basis is not understood. Using gene expression analysis, PNH granulocytes had relative overexpression of four anti-apoptosis genes (human A1, hHR23B, Mcl-1, and RhoA) compared to normal controls. These findings were confirmed by RT-PCR analysis and observed in both peripheral blood granulocytes and mononuclear cells of patients with PNH. Anti-apoptosis gene upregulation may confer resistance to apoptosis in PNH and related disorders, and provide a common compensatory mechanism after bone marrow injury that allows survival and growth of remaining hematopoietic stem cells. (C) 2003 Elsevier Science (USA). All rights reserved.