ERP AMPLITUDE AND SCALP DISTRIBUTION TO TARGET AND NOVEL EVENTS - EFFECTS OF TEMPORAL-ORDER IN YOUNG, MIDDLE-AGED AND OLDER ADULTS
ERP AMPLITUDE AND SCALP DISTRIBUTION TO TARGET AND NOVEL EVENTS - EFFECTS OF TEMPORAL-ORDER IN YOUNG, MIDDLE-AGED AND OLDER ADULTS
复制标题
DOI：
10.1016/0926-6410(94)90020-5
复制
发表时间：
1994-07-01
期刊：
影响因子：
--
通讯作者：
SIMPSON, GV
中科院分区：
文献类型：
--
作者：
FRIEDMAN, D;SIMPSON, GV
事件相关脑电位(ERPs)被记录在年轻人(平均年龄=24.1岁)、中年人(48.7岁)和老年人(69.7岁)的一个版本的古怪范式中，在48个独特的、意想不到的新刺激中，散布着同样罕见的指示目标。由于年长的人与年轻人相比，他们抑制任务无关信息处理的能力不同，根据之前的研究，我们预计，新的刺激在老年人身上保持“新颖性”的时间会比年轻人长。为了评估这一点，我们分析了小说和靶子诱发的P3波幅和头皮地形图作为区块内刺激数量(n=6)和区块数量(n=4)的函数。结果与预测一致：虽然年轻人的P3头皮分布随着区块内新数字的变化而从相对较前面的部位转移到相对较后面的部位，但这在老年人的头皮地形中并不明显。再加上老年人对新刺激的错误警报率上升，这些数据与额叶功能随着年龄的增长而变化是一致的。
Event-related brain potentials (ERPs) were recorded from young (mean age = 24.1), middle-aged (48.7) and older (69.7) adults during a version of the oddball paradigm, in which 48 unique, unexpected novel stimuli were interspersed with equally rare instructed targets. As older relative to younger adults are thought to differ in their ability to inhibit the processing of task irrelevant information, we expected, based on previous work, that novel stimuli would retain their 'novelty' longer in older than in younger adults. To assess this, P3 amplitude and scalp topography elicited by novels and targets were analyzed as a function of stimulus number (n = 6) within the block and as a function of block number (n = 4). The results were in line with the prediction: While the younger adults' P3 scalp distribution shifted from a relatively more frontal to a relatively more posterior focus as a function of novel number within the block, this was not evident in the scalp topographies of the older adults. Coupled with the older adults' elevated false alarm rates to novel stimuli, the data are consistent with a change in frontal lobe function with increases in age.