Sevoflurane degradation to compound A in anaesthesia breathing systems
Sevoflurane degradation to compound A in anaesthesia breathing systems
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DOI：
10.1093/bja/77.4.537
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发表时间：
1996-10-01
影响因子：
9.8
通讯作者：
Grabenkort, RW
中科院分区：
文献类型：
--
作者：
Cunningham, DD;Huang, S;Grabenkort, RW
通过确定有效速率常数和活化能，可以应用稳态理论从七氟烷浓度、新鲜气体流量、吸收剂温度和吸收剂用量预测化合物A的浓度。八个研究小组的研究进行了比较。在低流速下观察到的化合物A浓度低于预期，这表明在封闭和低流量呼吸系统中，吸收剂对化合物A的降解对于限制观察到的最大浓度很重要。在商业和中试工厂吸收剂的模型系统测试中，观察到化合物A浓度的试验与试验和批次之间的变化。用甘油对吸收剂进行化学改性，可能形成亲核加成产物，从而降低了化合物A的浓度。理想的化学清除剂在与化合物A发生不可逆反应形成稳定不挥发的产物之前，应在吸收剂中保持稳定不挥发。
Determination of an effective rate constant and activation energy allowed the application of steady-state theory to predict concentrations of compound A from sevoflurane concentrations, fresh gas flow rate, absorbent temperature and amount of absorbent. Studies by eight research groups were compared. Lower concentrations of compound A than predicted were observed at low flow rates, suggesting that its degradation by the absorbent is important in limiting the maximum observed concentrations in closed and low-flow breathing systems. Trial-to-trial and batch-to-batch variations in compound A concentrations were observed in model system tests of commercial and pilot-plant absorbents. Chemical modification of the absorbent with glycerol lowered concentrations of compound A, possibly by formation of a nucleophilic addition product. An ideal chemical scavenger would remain stable and non-volatile in the absorbent before irreversibly reacting with compound A to form a stable non-volatile product.