Quality of life in female patients with acromegaly
Quality of life in female patients with acromegaly
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DOI：
10.3275/8761
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发表时间：
2013-06-01
影响因子：
5.4
通讯作者：
Kadioglu, P.
中科院分区：
文献类型：
--
作者：
Celik, O.;Kadioglu, P.
目的：本研究旨在评估女性肢端肥大症患者的生活质量和抑郁状况。患者和方法：研究纳入了在Cerrahpasa医学院内分泌和代谢门诊接受随访的57例女性肢端肥大症患者（21例非活动性，36例活动性）。采用贝克抑郁量表（BDI）和肢端肥大症生活质量问卷（AcroQoL），根据疾病活动性评估患者的抑郁状态和生活质量。测定各组泌乳素、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E-2）、总睾酮和游离睾酮、硫酸脱氢表雄酮（DHEA-SO_4）、17 α-羟孕酮、雄烯二酮、游离甲状腺素（FT_4）、促甲状腺素（TSH）、皮质醇、GH和IGF-I。结果如下：控制性肢端肥大症和不控制性肢端肥大症女性患者的AcroQoL总分分别为45.5 [四分位距（IQR）= 32.9-57.4]和47.7 [（IQR）= 38.6-63.3]（p=0.53）。肢端肥大症患者根据疾病活动度的BDI评分无差异（p=0.41）。相关分析显示，AcroQoL总分与BDI评分呈显著负相关（r=-0.72，p
Aim: The aim of the study was to assess the quality of life and depression status in female patients with acromegaly. Patients and methods: Fifty-seven female patients with acromegaly (21 inactive, 36 active) who were being followed-up at the Cerrahpasa Medical School, Endocrinology and Metabolism out-patient clinic, were included in the study. Depression status and quality of life of the patients were evaluated according to disease activity using the Beck Depression Inventory (BDI) and the Acromegaly Quality of Life (AcroQoL) Questionnaire. Prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E-2), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), 17 alpha-hydroxyprogesterone, androstenedione, free thyroxin (FT4), thyrotropin (TSH), cortisol, GH and IGF-I were studied in the groups. Results: The AcroQoL total score in female patients with controlled acromegaly and uncontrolled acromegaly were 45.5 [Interquartile range (IQR)= 32.9-57.4], 47.7 [(IQR)= 38.6-63.3], respectively (p=0.53). There was no difference in BDI scores in acromegalic patients according to disease activity (p=0.41). In the correlation analysis, a strong negative correlation was found between AcroQoL total score and BDI score (r=-0.72, p