Evidence for common ancestry and microevolution of passerine-adapted Salmonella enterica serovar Typhimurium in the UK and USA.
Evidence for common ancestry and microevolution of passerine-adapted Salmonella enterica serovar Typhimurium in the UK and USA.
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DOI：
10.1099/mgen.0.000775
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发表时间：
2022-03
影响因子：
3.9
通讯作者：
Dudley EG
中科院分区：
文献类型：
--
作者：
Fu Y;Smith JC;Shariat NW;M'ikanatha NM;Dudley EG
的演变 肠道沙门氏菌 鼠伤寒血清型（S.在欧洲，雀形目动物中的鼠伤寒沙门氏菌（Typhimurium）导致该血清型对禽类宿主的病理适应。最近，我们发现了一个S。来自北美雀形目的鼠伤寒谱系。雀形目S.欧洲和北美的鼠伤寒引起了人们对其进化起源的质疑。在这里，我们证明了英国和美国的雀形目适应S。鼠伤寒有一个共同的祖先。1838年，落叶松通过传播北美和欧洲之间的共同祖先在克隆扩张中发挥了关键作用。此外，我们确定了毒力基因签名共同雀形目和落叶松适应S。鼠伤寒沙门氏菌，包括菌毛基因lpfD和3型分泌系统（T3 SS）效应基因steC中的保守假基因。然而，英国和美国的雀形目适应S。鼠伤寒沙门氏菌还具有独特的毒力基因特征（即菌毛基因fimC和T3 SS效应基因sspH 2、gogB、sseJ和sseK 2中的假基因），其中大多数（38/47）缺失了一个存在于适应落叶松的鼠伤寒沙门氏菌中的毒力质粒pxD。鼠伤寒这些结果为雀形目适应性S。鼠伤寒沙门氏菌与落叶松鼠伤寒沙门氏菌有共同的祖先，雀形目鼠伤寒沙门氏菌与落叶松鼠伤寒沙门氏菌的分化也存在一定的差异。鼠伤寒可能是由于假基因化或特定毒力基因的丢失。
The evolution of Salmonella enterica serovar Typhimurium (S. Typhimurium) within passerines has resulted in pathoadaptation of this serovar to the avian host in Europe. Recently, we identified an S. Typhimurium lineage from passerines in North America. The emergence of passerine-adapted S. Typhimurium in Europe and North America raises questions regarding its evolutionary origin. Here, we demonstrated that the UK and US passerine-adapted S. Typhimurium shared a common ancestor from ca. 1838, and larids played a key role in the clonal expansion by disseminating the common ancestor between North America and Europe. Further, we identified virulence gene signatures common in the passerine- and larid-adapted S. Typhimurium, including conserved pseudogenes in fimbrial gene lpfD and Type 3 Secretion System (T3SS) effector gene steC. However, the UK and US passerine-adapted S. Typhimurium also possessed unique virulence gene signatures (i.e. pseudogenes in fimbrial gene fimC and T3SS effector genes sspH2, gogB, sseJ and sseK2), and the majority of them (38/47) lost a virulence plasmid pSLT that was present in the larid-adapted S. Typhimurium. These results provide evidence that passerine-adapted S. Typhimurium share a common ancestor with those from larids, and the divergence of passerine- and larid-adapted S. Typhimurium might be due to pseudogenization or loss of specific virulence genes.