Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture.
Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture.
复制标题
成人血液中循环的红系祖细胞在培养物中产生胎儿血红蛋白。
作者：
T. Papayannopoulou;B. Nakamoto;J. Buckley;S. Kurachi;P. Nute;G. Stamatoyannopoulos
红系集落，从正常成年个体外周血中循环的红系干细胞中产生，合成大量的胎儿血红蛋白。在来自镰状化病症患者的培养物中，产生已知在体内抑制镰状化的血红蛋白F的量。结果提供的证据表明，原始红系祖细胞能够表达的血红蛋白F生产程序和成人血液的单核细胞的培养物可用于研究参与调节γ-珠蛋白基因开关的机制。
Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.