Adapting an Evidence-Based Intervention to Address Targeted Therapy-Related Fatigue in Chronic Myeloid Leukemia Patients.
Adapting an Evidence-Based Intervention to Address Targeted Therapy-Related Fatigue in Chronic Myeloid Leukemia Patients.
复制标题
采用循证干预措施来解决慢性粒细胞白血病患者与靶向治疗相关的疲劳。
DOI：
10.1097/ncc.0000000000000446
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发表时间：
2018
期刊：
影响因子：
2.6
通讯作者：
Jacobsen,PaulB
中科院分区：
文献类型：
--
作者：
Poort,Hanneke;Meade,CathyD;Knoop,Hans;Gielissen,MariekeFM;Pinilla-Ibarz,Javier;Jacobsen,PaulB
背景：疲劳是慢性粒细胞白血病（CML）口服靶向治疗患者经历的最重要的生活质量问题之一。然而，没有干预存在，具体解决战略，以减少有针对性的治疗相关fatigue.Objective：本研究适应了循证临床提供的干预（EBI）“认知行为治疗癌症后疲劳”用于CML患者。现有的EBI是基于6个已建立的持久疲劳因素（即睡眠，活动，有益的思维，应对癌症，社会支持和对疾病复发的恐惧）。研究的目的是衡量反应（1）现有的内容和（2）一个新的互联网辅助的干预交付format.Methods：指导下的ADAPT-ITT框架，我们使用了一系列系统的步骤和适应方法，包括半结构化的采访CML患者和供应商和反馈专题expertes.Results：患者接受现有的内容主题和互联网辅助交付格式是可以接受的。一个关键的主题反映了需要一个新的定制的关于慢性粒细胞白血病作为一种疾病及其治疗的心理教育模块。提供者和患者都对适应EBI的潜力，以改善fatigue.Conclusions：调查结果提供了必要的指导，适应和加强实用的适应intervention.Implications实践：适应现有的EBI为新的受众有助于推进循证研究的结果，最终提供护士和其他医疗服务提供者的重要转介选项的干预措施，可以提供有用的策略，以提高生活质量和减少有针对性的治疗相关的疲劳。
Background:Fatigue is one of the most important quality of life issues experienced by patients being treated with oral targeted therapy for chronic myeloid leukemia (CML). However, no intervention exists that specifically addresses strategies to reduce targeted therapy–related fatigue.Objective:This study adapted an evidence-based clinic-delivered intervention (EBI)“cognitive behavior therapy for post-cancer fatigue” for use in CML patients. The existing EBI was based on 6 established perpetuating factors of fatigue (ie, sleep, activity, helpful thinking, coping with cancer, social support, and fear of disease recurrence). Study aims were to gauge reactions to (1) existing content and (2) a new Internet-assisted intervention delivery format.Methods:Guided by the ADAPT-ITT framework, we used a series of systematic steps and adaptation methodologies, including semistructured interviews with CML patients and providers and feedback from topical experts.Results:Patients were receptive to existing content topics and an Internet-assisted delivery format was acceptable. A key theme reflected the need for a new customized psychoeducational module about CML as a disease and its treatment. Both providers and patients held positive views about the potential of the adapted EBI to improve fatigue.Conclusions:Findings offered essential guidance for the adaptation and reinforced the utility of the adapted intervention.Implications for Practice:Adapting existing EBIs for new audiences contributes to advancing findings of evidence-based research, ultimately providing nurses and other healthcare providers with important referral options to interventions that may provide useful strategies to improve quality of life and reduce targeted therapy–related fatigue.