ATHYMIC NUDE MUTATION IN RAT
ATHYMIC NUDE MUTATION IN RAT
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DOI：
10.1038/274365a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
SPARROW, S
中科院分区：
文献类型：
--
作者：
FESTING, MFW;MAY, D;SPARROW, S
1953年，在Rowett研究所饲养的一群远系繁殖的带帽大鼠中观察到无胸腺无毛突变。突变动物的繁殖群一直难以维持，直到20世纪60年代初才消失。然而，隐性突变基因（Rowett裸色的符号nufor已分配给该基因）在随机繁殖的菌落内显然保持在低基因频率。1975年恢复了纯合突变体，并再次建立了育种群体，首先在常规条件下，后来在无菌条件下，获得了良好的育种性能和存活率。1977年2月，在MRC实验动物中心，在常规、无菌和无特定病原体的条件下建立了这些大鼠的繁殖核心。本文报告的观察结果和数据是在清洁、常规条件下饲养的少量动物中获得的，表明裸大鼠在生物医学研究中的潜在用途。
IN 1953 an athymic hairless mutation was observed in a colony of outbred hooded rats maintained at the Rowett Research Institute. A breeding colony of mutant animals was maintained with difficulty until the early 1960s, when it died out. However, the recessive mutant gene (to which the symbolrnufor Rowett nude has been assigned) was apparently maintained at low gene frequency within the random bred colony. Homozygous mutants were recovered in 1975, and a breeding colony was again established, first in conventional, and later in germ-free conditions, where good breeding performance and survival were obtained. In February 1977 a breeding nucleus of these rats was established at the MRC Laboratory Animals Centre in conventional, germ-free and specific pathogen-free conditions. The observations and data reported here were obtained with small numbers of animals bred in clean, conventional conditions, and suggest the potential usefulness of nude rats in biomedical research.