Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.
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DOI：
10.1097/jom.0b013e31829b290b
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发表时间：
2013-10
影响因子：
3.2
通讯作者：
LeVan TD
中科院分区：
文献类型：
--
作者：
Goldner WS;Sandler DP;Yu F;Shostrom V;Hoppin JA;Kamel F;LeVan TD
在农业健康研究中，评估男性施用者甲状腺疾病与使用杀虫剂、除草剂、熏蒸剂/杀真菌剂之间的关联。我们研究了22,246名男性农药使用者使用50种特定农药与自我报告的甲状腺功能减退症、甲状腺功能亢进症和“其他”甲状腺疾病之间的关系。有甲状腺功能减退症的几率增加与以往使用的除草剂2，4-D，2，4，5-T，2，4，5-TP，甲草胺，麦草畏，和石油。甲状腺功能减退症还与曾经使用过的八种杀虫剂有关：有机氯农药氯丹、滴滴涕、七氯、林丹和毒杀芬;有机磷农药二嗪农和马拉硫磷;以及氨基甲酸酯呋喃丹。暴露-反应分析表明，除草剂甲草胺和2，4-D以及杀虫剂艾氏剂、氯吡格雷、滴滴涕、林丹和氯吡格雷的暴露水平越高，几率越大。甲状腺功能减退症和特定的除草剂和杀虫剂在男性施药者之间存在关联，类似于以前对配偶的结果。
Evaluate the association between thyroid disease and use of insecticides, herbicides, fumigants/fungicides in male applicators in the Agricultural Health Study. We examined the association between use of 50 specific pesticides and self-reported hypothyroidism, hyperthyroidism, and ‘other’ thyroid disease among 22,246 male pesticide applicators. There was increased odds of hypothyroidism with ever-use of the herbicides 2,4-D, 2,4,5-T, 2,4,5-TP, alachlor, dicamba, and petroleum oil. Hypothyroidism was also associated with ever-use of eight insecticides: organochlorines chlordane, DDT, heptachlor, lindane, and toxaphene; organophosphates diazinon and malathion; and the carbamate carbofuran. Exposure-response analysis showed increasing odds with increasing level of exposure for the herbicides alachlor and 2,4-D, and the insecticides aldrin, chlordane, DDT, lindane, and parathion. There is an association between hypothyroidism and specific herbicides and insecticides in male applicators, similar to previous results for spouses.