CEREBRAL MICROCIRCULATION IN THE MOUSE BRAIN. SPONTANEOUS AND DRUG-INDUCED CHANGES IN FLOW AND VASCULAR DIAMETER.
CEREBRAL MICROCIRCULATION IN THE MOUSE BRAIN. SPONTANEOUS AND DRUG-INDUCED CHANGES IN FLOW AND VASCULAR DIAMETER.
复制标题
小鼠大脑中的脑微循环。
作者：
W. Rosenblum;B. Zweifach
一些报告表明，可以局部应用于大脑表面血管的药物，以及在其他血管床上具有显著收缩特性的药物，对脑血管只产生最小的影响。1-3例如，脑血管床对儿茶酚胺的反应如此之差，以至于完全不能代表血管的反应性。大脑动脉对呼吸气体的反应表明，它们的直径变化要大得多。4-6当检查小血管时，研究脑动脉反应性的问题变得更加困难，因为它们的大小排除了对肾上腺素或左旋肾上腺素(去甲肾上腺素)刺激后可能发生的直径微小变化的可靠估计。此外，几位作者只报道了儿茶酚对较小的软脑膜动脉或小动脉的不同或不一致的影响。毫无疑问，进一步研究这些化合物的反应性是很重要的
Several reports indicate that agents which can be topically applied to the vessels on the cerebral surface, and which have marked vasoconstrictive properties in other vascular beds, produce only minimal effects on the cerebral vessels. 1-3 For example, the response of the cerebrovascular bed to catechol amines is so poor as to provide a totally inadequate representation of vascular reactivity. Cerebral arteries are capable of much greater alterations of diameter as shown by their responses to respiratory gases. 4-6 The problem of studying cerebroarterial reactivity is made even more difficult when small vessels are examined, since their size precludes reliable estimation of the small changes in diameter which may follow stimulation with epinephrine or levarterenol (norepinephrine). Moreover, several authors report only variable or inconsistent effects of catechols on the smaller pial arteries or arterioles. 2,3 There is little doubt that it is important to study further the reactivity of these