Serum antibodies against alcohol-treated rabbit hepatocytes in patients with alcoholic liver disease.
Serum antibodies against alcohol-treated rabbit hepatocytes in patients with alcoholic liver disease.
复制标题
酒精性肝病患者针对经酒精处理的兔肝细胞的血清抗体。
DOI：
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复制
发表时间：
1985
影响因子：
4.6
通讯作者：
J. Takeuchi
中科院分区：
文献类型：
--
作者：
N. Izumi;C. Sato;Y. Hasumura;J. Takeuchi
The existence of antibodies against alcohol-treated rabbit hepatocytes in sera of patients with alcoholic liver disease was investigated utilizing a 125I-labelled protein A assay. The sera, after two absorptions with normal rabbit hepatocytes, were incubated with hepatocytes isolated from rabbits which had been treated for 4 days with a daily dose of ethanol (1 g/kg body weight) intravenously. Serum antibodies against alcohol-treated hepatocytes were detected in 21 of 55 patients with alcoholic liver disease; this was associated with a distinct, mixed granular and linear fluorescence staining the surface of alcohol-treated hepatocytes. By contrast, none of 23 patients with other liver diseases who had no history of excessive alcohol intake showed the antibodies in their sera. The values of the antibodies of patients with alcoholic active cirrhosis and alcoholic hepatitis were significantly higher than those of other types of alcoholic liver disease. These results showed that antibodies against alcohol-treated hepatocytes are present in alcoholic liver disease with inflammation. The role of these antibodies on liver cell damage in alcoholic liver disease remains to be clarified.
