Diffusion Tensor Imaging (DTI) of the Brain in Moving Subjects: Application to In-Utero Fetal and Ex-Utero Studies
Diffusion Tensor Imaging (DTI) of the Brain in Moving Subjects: Application to In-Utero Fetal and Ex-Utero Studies
复制标题
DOI：
10.1002/mrm.22032
复制
发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Hajnal, Joseph V.
中科院分区：
文献类型：
--
作者：
Jiang, Shuzhou;Xue, Hui;Hajnal, Joseph V.
我们提出了一种方法来实现三维高分辨率的扩散张量图像重建的大脑在移动的主题。源数据是扩散敏感单次激发回波平面图像。在连续扫描以获取具有15个扩散方向的一系列重复的平行切片之后，使用图像配准来重新对准图像以校正受试者运动。一旦对准，扩散图像被视为不规则采样的数据，其中每个体素与适当旋转的扩散方向相关联。该数据用于在规则网格上估计扩散张量。该方法已在1.5T采集的数据进行了测试，从成年人故意移动，并从8个胎儿在子宫内成像。在所有情况下，表观扩散系数（ADC）图都是可靠的，分数各向异性图的性能也很好。正常胎儿大脑的结果与已发表的相似胎龄早产儿的数据一致。Magn Reson Med 62：645-655，2009. (C)2009 Wiley-Liss，Inc.
We present a methodology to achieve 3D high-resolution diffusion tensor image reconstruction of the brain in moving subjects. The source data is diffusion-sensitized single-shot echo-planar images. After continuous scanning to acquire a repeated series of parallel slices with 15 diffusion directions, image registration is used to realign the images to correct for subject motion. Once aligned, the diffusion images are treated as irregularly-sampled data where each voxel is associated with an appropriately rotated diffusion direction. This data is used to estimate the diffusion tensor on a regular grid. The method has been tested on data acquired at 1.5T from adults who deliberately moved and from eight fetuses imaged in utero. Maps of apparent diffusion coefficient (ADC) were reliably produced in all cases and promising performance was achieved for fractional anisotropy maps. Results from normal fetal brains were found to be consistent with published data from premature infants of similar gestational age. Magn Reson Med 62: 645-655, 2009. (C) 2009 Wiley-Liss, Inc.