Role of prehypertension in the development of coronary atherosclerosis in Japan.
Role of prehypertension in the development of coronary atherosclerosis in Japan.
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DOI：
10.2188/jea.14.57
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发表时间：
2004-03
影响因子：
4.7
通讯作者：
Koyanagi S
中科院分区：
文献类型：
--
作者：
Washio M;Tokunaga S;Yoshimasu K;Kodama H;Liu Y;Sasazuki S;Tanaka K;Kono S;Mohri M;Takeshita A;Arakawa K;Ideishi M;Nii T;Shirai K;Arai H;Doi Y;Kawano T;Nakagaki O;Takada K;Hiyamuta K;Koyanagi S
背景：高血压是冠心病的重要危险因素。美国高血压预防、检测、评估和治疗联合国家委员会第七次报告中的高血压预防和管理新指南建议对高血压前期受试者进行生活方式改变或药物治疗。然而，高血压前期是否会增加日本人群冠状动脉粥样硬化的风险仍然未知。方法：在临床环境中进行横断面研究。受试者为705名年龄在30岁及以上的患者（417名男性和288名女性），他们于1996年9月至1997年8月期间在福冈都会区的5个主要心脏科因疑似或已知的冠心病接受了首次冠状动脉造影。研究结果：与血压正常的受试者相比，即使在调整了其他因素后，高血压前期的受试者患冠状动脉粥样硬化的风险也会增加。结论：高血压前期可能是一个重要的临床实体，需要在日本人口的治疗。
BACKGROUND: Hypertension is an important risk factor of coronary heart disease. A new guidelines for hypertension prevention and management in The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in the United States recommended lifestyle modification or medical treatment for subjects with prehypertension. However, whether prehypertension increases the risk of coronary atherosclerosis in the Japanese population is still unknown. METHODS: A cross-sectional study in a clinical setting was conducted. The subjects were 705 patients (417 males and 288 females) aged 30 years and older who underwent a first-time coronary angiography for suspected or known coronary heart disease at 5 major cardiology departments in the Fukuoka metropolitan area between September 1996 and August 1997. RESULTS: Compared to subjects with normal blood pressure, those with prehypertension had an increased risk of coronary atherosclerosis even after adjusting for other factors. CONCLUSION: Prehypertension may be an important clinical entity which requires treatment in the Japanese population.