Anorexia in chronic obstructive pulmonary disease - Association to cachexia and hormonal derangement
Anorexia in chronic obstructive pulmonary disease - Association to cachexia and hormonal derangement
复制标题
DOI：
10.1016/j.ijcard.2006.07.088
复制
发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
John, Matthias
中科院分区：
文献类型：
--
作者：
Koehler, Friedrich;Doehner, Wolfram;John, Matthias
背景资料：在患有慢性阻塞性肺病（COPD）的患者中，经常发生体重减轻，这可能最终导致恶病质作为严重的并发症，表明功能能力、健康状况严重受损和死亡率增加。由于机械和代谢效率低下以及全身炎症导致的能量消耗增加是饮食摄入不平衡的高代谢状态的决定因素。厌食症可能对COPD患者的体重减轻有重要作用，然而，免疫和激素紊乱与食欲改变之间的关系尚未得到详细研究。目的：本研究的目的是调查COPD患者的厌食症是否与炎症和激素紊乱有关，这些因素与体重减轻有关。方法：我们前瞻性地纳入了103例COPD患者（年龄59.8 +/- 1.3岁，35%为女性，平均FEV 1 38.3 +/- 1.7%）与相似年龄的健康对照组（n= 15）相比。在34名患者（33%）中诊断出恶病质（体重减轻> 7.5%，BMI
Background: In patients with chronic obstructive pulmonary disease ( COPD) weight loss frequently occurs that may ultimately lead to cachexia as a serious co- morbidity, indicating severely impaired functional capacity, health status and increased mortality. Increased energy expenditure due to mechanic and metabolic inefficiency and systemic inflammation are determinants of a hypermetabolic state that is not balanced by dietary intake. Anorexia may importantly contribute to weight loss in COPD, however, the association between immune and hormonal derangement and altered appetite has not been studied in detail.Aim: The aim of the present study was to investigate whether anorexia in COPD is related to inflammation and hormonal derangement in association to weight loss.Methods: We prospectively enrolled 103 consecutive patients with COPD (age 59.8 +/- 1.3 years, 35% female, mean FEV1 38.3 +/- 1.7%) in comparison to healthy controls of similar age (n= 15).Results: In 34 patients ( 33%) cachexia was diagnosed ( weight loss > 7.5%, BMI