Galvanic vestibular stimulation-induced activation of C1 neurons in medulla oblongata protects against acute lung injury.
Galvanic vestibular stimulation-induced activation of C1 neurons in medulla oblongata protects against acute lung injury.
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电前庭刺激诱导的延髓 C1 神经元激活可预防急性肺损伤。
DOI：
10.1152/ajpregu.00131.2022
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Morita H.
中科院分区：
文献类型：
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作者：
Abe C;Katayama C;Ohbayashi K;Horii K;Ogawa B;Fujimoto C;Iwasaki Y;Nin F;Morita H.
自主神经，包括交感神经和副交感神经，控制免疫系统沿着它们的生理功能。在外周侧，脾交感神经和免疫细胞之间的相互作用对于抗炎作用是重要的。然而，这些抗炎作用的核心机制仍不清楚。C1神经元对应激源作出反应，随后决定自主神经系统的流出。我们以前已经表明，C1神经元保护急性肾损伤，并发现外周前庭器官和C1神经元之间的信号连接。因此，我们假设超重力负荷或前庭电刺激（GVS）可能会保护急性肺损伤。我们发现，C1神经元的组织和功能激活刺激外周前庭器官。由于前庭损伤或C1神经元缺失，2G负荷引起的急性肺损伤的保护作用消失。这种GVS诱导的保护作用也被C1神经元的缺失所消除。此外，GVS增加清醒小鼠脾交感神经活动，脾交感神经去神经取消GVS诱导的对急性肺损伤的保护作用。因此，C1神经元和脾交感神经之间的激活通路在GVS诱导的急性肺损伤保护中是必不可少的。
Autonomic nerves, including the sympathetic and parasympathetic nerves, control the immune system along with their physiological functions. On the peripheral side, the interaction between the splenic sympathetic nerves and immune cells is important for the anti-inflammatory effects. However, the central mechanism underlying these anti-inflammatory effects remains unclear. C1 neurons respond to stressors and subsequently determine the outflow of the autonomic nervous system. We have previously shown that C1 neurons protect against acute kidney injury and found a signaling connection between peripheral vestibular organs and C1 neurons. Thus, we hypothesized that hypergravity load or galvanic vestibular stimulation (GVS) might protect against acute lung injury. We showed that C1 neurons are histologically and functionally activated by stimulating the peripheral vestibular organs. Protection against acute lung injury that was induced by a 2 G load disappeared due to vestibular lesions or the deletion of C1 neurons. This GVS-induced protective effect was also eliminated by the deletion of the C1 neurons. Furthermore, GVS increased splenic sympathetic nerve activity in conscious mice, and splenic sympathetic denervation abolished the GVS-induced protection against acute lung injury. Therefore, the activated pathway between C1 neurons and splenic sympathetic nerves is indispensable for GVS-induced protection against acute lung injury.