Sex differences in gene expression in the human fetal brain
Sex differences in gene expression in the human fetal brain
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DOI：
10.1101/483636
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发表时间：
2018-11
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影响因子：
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通讯作者：
Heath E. O’Brien;E. Hannon;A. Jeffries;W. Davies;M. Hill;R. Anney;M. O’Donovan;J. Mill;N. Bray
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文献类型：
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作者：
Heath E. O’Brien;E. Hannon;A. Jeffries;W. Davies;M. Hill;R. Anney;M. O’Donovan;J. Mill;N. Bray
据报道，男性和女性人类大脑之间存在广泛的结构、化学和分子差异。尽管几种神经发育障碍在男性中更常见，但人们对早期人类大脑发育的性别差异知之甚少。在这里，我们使用来自妊娠中期 (N = 120) 的大量人类大脑样本的 RNA 测序数据来评估人类胎儿大脑内基因表达的性别偏见。除了从男性 Y 染色体转录的 43 个基因（102 个 Ensembl 转录本）之外，我们还检测到 2558 个常染色体基因（2723 个 Ensembl 转录本）和 X 染色体上的 155 个基因（207 个 Ensembl 转录本）的表达存在性别差异，错误发现率 (FDR) < 0.1。人类胎儿大脑中表现出性别偏向表达的基因富含自闭症和其他发育障碍的高可信度风险基因。偏向雄性的基因在神经祖细胞中富集表达，而偏向雌性的基因在Cajal-Retzius细胞和神经胶质细胞中富集表达。所有基因和转录水平数据均作为在线资源提供（可在http://fgen.psycm.cf.ac.uk/FBSeq1获取），研究人员可以通过该资源搜索、下载和可视化与早期人类大脑发育过程中基因表达性别偏见有关的数据。
Widespread structural, chemical and molecular differences have been reported between the male and female human brain. Although several neurodevelopmental disorders are more commonly diagnosed in males, little is known regarding sex differences in early human brain development. Here, we used RNA sequencing data from a large collection of human brain samples from the second trimester of gestation (N = 120) to assess sex biases in gene expression within the human fetal brain. In addition to 43 genes (102 Ensembl transcripts) transcribed from the Y-chromosome in males, we detected sex differences in the expression of 2558 autosomal genes (2723 Ensembl transcripts) and 155 genes on the X-chromosome (207 Ensembl transcripts) at a false discovery rate (FDR) < 0.1. Genes exhibiting sex-biased expression in human fetal brain are enriched for high-confidence risk genes for autism and other developmental disorders. Male-biased genes are enriched for expression in neural progenitor cells, whereas female-biased genes are enriched for expression in Cajal-Retzius cells and glia. All gene- and transcript-level data are provided as an online resource (available at http://fgen.psycm.cf.ac.uk/FBSeq1) through which researchers can search, download and visualize data pertaining to sex biases in gene expression during early human brain development.