Clinical Indications for Growth Hormone Therapy.

Clinical Indications for Growth Hormone Therapy.
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DOI:
10.1016/j.yapd.2022.03.005
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发表时间:
2022-08
影响因子:
--
通讯作者:
Grimberg, Adda
Grimberg, Adda
中科院分区:
其他
文献类型:
--
作者:
Danowitz, Melinda;Grimberg, Adda

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生长激素治疗包括每晚皮下注射,试图反映垂体的内源性生长激素分泌。GH治疗是昂贵的,每个孩子每年的中位数费用超过25,000美元[69]。尽管如此,从2001年至2016年,美国儿科人群的GH使用几乎增加了两倍[69]。在过去的35年中,儿科GH治疗已从最初的适应症扩展到纠正GHD,现在使用药物来增加内源性GH产生的条件下的身高。
GH treatment involves nightly subcutaneous injections in attempt to mirror the pituitary’s endogenous GH secretion. GH therapy is expensive, with median costs per child exceeding $25,000 annually [69]. Nonetheless, GH use in the US pediatric population almost tripled from 2001 to 2016 [69]. Over the past 35 years, pediatric GH treatment has expanded from its initial indication to correct GHD, to now using the medication to increase height in conditions whereby endogenous GH production is