Spectrum of clinical presentation, treatment and prognosis in a series of eight patients with leukaemia cutis
Spectrum of clinical presentation, treatment and prognosis in a series of eight patients with leukaemia cutis
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DOI：
10.1111/j.1365-2230.2005.02022.x
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发表时间：
2006-03-01
影响因子：
4.1
通讯作者：
Creamer, D
中科院分区：
文献类型：
--
作者：
Watson, KMT;Mufti, G;Creamer, D
所有类型的白血病都可以扩散到皮肤，产生皮肤沉积物，称为皮肤白血病(LC)。我们进行了一项回顾性研究，回顾了我科12年来收治的8例LC患者的临床表现、治疗和转归。临床表现多种多样，以红斑丘疹和结节最常见。还可见浸润性出血斑块和小叶周围痤疮样丘疹。虽然患者对其潜在的白血病进行了积极的治疗，并接受了针对LC的治疗，但他们往往难以治疗，而且诊断通常与预后不良有关。一个例外是慢性淋巴细胞白血病患者，他在发展为LC后存活了3年。
All types of leukaemia can disseminate to the skin, producing cutaneous deposits known as leukaemia cutis (LC). We undertook a retrospective study to review the clinical presentations, treatment and outcome of eight patients with LC managed in our department over a period of 12 years. The clinical phenotype varied, with erythematous papules and nodules occurring with greatest frequency. Infiltrated haemorrhagic plaques and perifollicular acneiform papules were also seen. Although patients were treated aggressively for their underlying leukaemia, and received therapy directed towards LC, they tended to be refractory to treatment and the diagnosis was generally associated with a poor prognosis. The exception was a patient with chronic lymphocytic leukaemia, who survived 3 years after developing LC.