Role of CXCR3 in the immune response to murine gammaherpesvirus 68
Role of CXCR3 in the immune response to murine gammaherpesvirus 68
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DOI：
10.1128/jvi.79.14.9351-9355.2005
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发表时间：
2005-07-01
影响因子：
5.4
通讯作者：
Sarawar, SR
中科院分区：
文献类型：
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作者：
Lee, BJ;Giannoni, F;Sarawar, SR
趋化因子IP-10（CXCL 10）及其细胞受体CXCR 3在鼠γ疱疹病毒68（MHV-68）感染期间在肺中上调。为了确定CXCR 3趋化因子受体在对MHV-68的免疫应答中的作用，用该病毒感染CXCR 3（-/-）小鼠。CXCR 3（-/-）小鼠表现出从肺中清除复制型MHV-68的延迟。这与延迟的T细胞募集到肺部和病毒清除前细胞溶解活性降低相关。脾肿大和每个脾脏潜伏感染细胞的数量短暂增加。然而，CXCR 3（-/-）小鼠显示正常的病毒特异性抗体滴度和有效的长期控制MHV-68感染。
The chemokine IP-10 (CXCL10) and its cellular receptor CXCR3 are upregulated in the lung during murine gammaherpesvirus 68 (MHV-68) infection. In order to determine the role of the CXCR3 chemokine receptor in the immune response to MHV-68, CXCR3(-/-) mice were infected with the virus. CXCR3(-/-) mice showed delayed clearance of replicating MHV-68 from the lungs. This correlated with delayed T-cell recruitment to the lungs and reduced cytolytic activity prior to viral clearance. Splenomegaly and the numbers of latently infected cells per spleen were transiently increased. However, CXCR3(-/-) mice showed normal virus-specific antibody titers and effective long-term control of MHV-68 infection.