Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action.
Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action.
复制标题
高密度脂蛋白的心脏保护作用超出了其抗动脉粥样硬化作用。
DOI：
10.5551/jat.rv17025
复制
发表时间：
2018-10-01
影响因子：
4.4
通讯作者：
Ishida T
中科院分区：
文献类型：
--
作者：
Nagao M;Nakajima H;Toh R;Hirata KI;Ishida T
高密度脂蛋白胆固醇（HDL-C）已被确定为心血管疾病的强大独立负预测因子。 HDL 的有益作用很大程度上归因于其在反向胆固醇转运中的关键作用，即外周组织中多余的胆固醇被转运至肝脏，从而减轻动脉粥样硬化负担。然而，越来越多的证据表明，HDL 还具有多效特性，例如抗炎、抗氧化和血管舒张特性，这可能有助于降低心力衰竭的发生率。事实上，之前的临床和实验研究数据表明，无论是否存在冠状动脉疾病，HDL 都能发挥心脏保护作用。这篇综述总结了目前可获得的证据，表明高密度脂蛋白除了抗动脉粥样硬化特性之外，还对心脏有益。了解 HDL 的心脏保护机制将为心力衰竭的潜在机制和治疗策略提供新的见解。
High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is transported to the liver, reducing the atherosclerotic burden. However, mounting evidence indicates that HDL also has pleiotropic properties, such as anti-inflammatory, anti-oxidative, and vasodilatory properties, which may contribute in reducing the incidence of heart failure. Actually, previous data from clinical and experimental studies have suggested that HDL exerts cardioprotective effects irrespective of the presence/absence of coronary artery disease. This review summarizes the currently available evidence regarding beneficial effects of HDL on the heart beyond its anti-atherogenic property. Understanding the mechanisms of cardiac protection by HDL will provide new insight into the underlying mechanism and therapeutic strategy for heart failure.