The Clinical High-Risk State for Psychosis (CHR-P), Version II
The Clinical High-Risk State for Psychosis (CHR-P), Version II
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DOI：
10.1093/schbul/sbw158
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发表时间：
2017-01-01
影响因子：
6.6
通讯作者：
Fusar-Poli, Paolo
中科院分区：
文献类型：
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作者：
Fusar-Poli, Paolo
临床精神病高危状态(CHR-P)范式是在大约20年前引入的。在这段时间里，积累了知识。概念上的进展涉及风险丰富的新知识和招募策略的影响，预测精神病和非精神病精神障碍的特异性，以及不同CHR-P亚组之间精神疾病风险的异质性。本期特刊在解构CHR-P范式的三个亚组中推进了当前的知识：遗传风险、减轻的精神病症状以及短暂和缓解的精神病发作。本文建议对该范式进行概念性修订(版本II)，并由本期发表的3项原创性研究提供支持。
The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago. Over this period of time accumulating knowledge has been gained. Conceptual advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and nonpsychotic mental disorders and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue.