Cholesterol as a Mediator of Alcohol-Induced Risks for Respiratory Disease Hospitalizations among People Living With HIV.
Cholesterol as a Mediator of Alcohol-Induced Risks for Respiratory Disease Hospitalizations among People Living With HIV.
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DOI：
10.4172/2155-6113.s1-001
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
M. Míguez;R. Rosenberg;X. Burbano;R. Malow
中科院分区：
文献类型：
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作者：
M. Míguez;R. Rosenberg;X. Burbano;R. Malow
我们分析了胆固醇作为酒精增加HIV感染者（PLWH）呼吸道感染风险的潜在介质的作用。采用纵向临床为基础的设计，346 PLWH连续入院，并在杰克逊纪念医学中心（入组研究）。根据国家指南，根据胆固醇水平对PLWH进行分层：200 mg/dl高胆固醇血症=HyperCHL），并根据临床结局、淋巴细胞表型和行为风险进行比较。分析表明，与HyperCHL参与者相比，HypoCHL受试者更有可能住院，特别是下呼吸道感染（LRTI）。过多的入院与更多的异常淋巴细胞谱，特别是有限的NK细胞。在Logistic回归分析中，吸烟（OR=1.5）、低CHL（OR=7.7）和饮酒（OR=1.2）是下呼吸道感染的预测因子。这些发现值得进一步调查的潜在用途HypoCHL作为一个风险标志，和成本效益的切换预防齿轮对HypoCHL，酒精和烟草在PLWH。
We analyzed the role of cholesterol as a potential mediator of alcohol-increased risk of respiratory infections that required hospitalization in People Living with HIV (PLWH). Using a longitudinal clinic-based design, 346 PLWH were consecutively admitted and followed at Jackson Memorial Medical Center(enrolled in the study). Following national guidelines, PLWH were stratified according to cholesterol levels: 200 mg/dl Hypercholesterolemia =HyperCHL), and compared on the basis of clinical outcomes, lymphocyte phenotypes and behavioral risks. Analyses indicated that compared to HyperCHL participants, HypoCHL subjects were more likely to be hospitalized, particularly for lower respiratory tract infections (LRTI). Excessive admissions were associated with more deviant lymphocyte profiles, particularly limited NK cells. In logistic regression analyses, smoking (OR=1.5), HypoCHL (OR=7.7), and alcohol (OR=1.2) were predictors of LRTI. These findings warrant further investigation of the potential use of HypoCHL as a risk marker, and the cost-effectiveness of switching prevention gears towards HypoCHL, alcohol and tobacco in PLWH.