Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits?: A meta-analysis
Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits?: A meta-analysis
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DOI：
10.1038/sj.mp.4001627
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发表时间：
2005-04-01
影响因子：
11
通讯作者：
Flint, J
中科院分区：
文献类型：
--
作者：
Munafò, MR;Clark, T;Flint, J
我们试图复制最近两项荟萃分析的结果，即个性问卷缓和了5-羟色胺转运体基因和焦虑相关特征之间的联系。共有24项研究参与了荟萃分析，其中3项报告的基因频率偏离了Hardy-Weinberg(HW)平衡。我们发现了一些支持的观点，即结果取决于所使用的问卷类型，尽管方向与先前报告的相反。S/S组和L/L组之间的对比在TCI/TPQ伤害回避研究中具有统计学意义(P=0.0024)，而在新神经质倾向的研究中无统计学意义(P=0.9757)。排除非HW平衡的研究后，S/S等位基因的tci/tpq结果仍超过我们的5%阈值，但显著性降低(P=0.0082)，而neo结果仍无显著意义(P=0.9109)。虽然我们不能排除5HTT基因与焦虑相关特征之间的关联，特别是在TCI/TPQ伤害避免方面，但我们的发现确实表明，如果存在的话，这种影响是很小的。我们的结果强调了完全确定研究和确定相关异质性来源的重要性。
We attempted to replicate the findings of two recent meta-analyses that personality inventory moderates the association between the serotonin transporter gene and anxiety-related traits. A total of 24 studies contributed to the meta-analysis, of which three reported genotype frequencies that deviated from Hardy - Weinberg (HW) equilibrium. We found some support for the view that results depend on the type of questionnaire used, although in a direction opposite to that previously reported. Contrasts between the S/S and L/L groups were significant for TCI/TPQ harm avoidance studies ( P = 0.0024) but not NEO neuroticism ( P = 0.9757). When studies not in HW equilibrium were excluded the TCI/TPQ result for the S/S genotype still exceeded our 5% threshold, although with reduced significance ( P = 0.0082), and the NEO result remained nonsignificant ( P = 0.9109). While we cannot rule out an association between the 5HTT gene and anxiety-related traits, particularly for TCI/TPQ harm avoidance, our findings do indicate that the effect, if present, is small. Our results emphasise the importance of complete ascertainment of studies and the identification of relevant sources of heterogeneity.