INTERACTIONS OF 3 SEQUENTIALLY EXPRESSED GENES CONTROL TEMPORAL AND SPATIAL SPECIFICITY IN ASPERGILLUS DEVELOPMENT
INTERACTIONS OF 3 SEQUENTIALLY EXPRESSED GENES CONTROL TEMPORAL AND SPATIAL SPECIFICITY IN ASPERGILLUS DEVELOPMENT
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DOI：
10.1016/0092-8674(89)90800-3
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发表时间：
1989-06-02
期刊：
影响因子：
64.5
通讯作者：
TIMBERLAKE, WE
中科院分区：
文献类型：
--
作者：
MIRABITO, PM;ADAMS, TH;TIMBERLAKE, WE
Aspergillus nidulans brlA, abaA, and wetA form a dependent pathway that regulates asexual reproductive development. The order in which these genes are expressed determines the outcome of development. Expression of brlA in vegetative cells leads to activation of abaA and wetA, cessation of vegetative growth, cellular vacuolization, and spore formation. By contrast, expression of abaA in vegetative cells does not result in conidial differential but does lead to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization. brlA, abaA, and wetA act individually and together to regulate their own expression and that of numerous other sporulation-specific genes. We propose tht the central pathway controlling development is largely autoregulatory. The timing and extent of expression of the regulatory genes and their targets are determined as development proceeds by intrinsically controlled changes in the relative concentrations of regulatory gene products in the various conidiophore cell types.
