Long-Term Follow-Up on Health-Related Quality of Life After Mechanical Circulatory Support in Children
Long-Term Follow-Up on Health-Related Quality of Life After Mechanical Circulatory Support in Children
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DOI：
10.1097/pcc.0000000000001019
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发表时间：
2017-02-01
影响因子：
4.1
通讯作者：
Stiller, Brigitte
中科院分区：
文献类型：
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作者：
Fleck, Thilo P. K.;Dangel, Georg;Stiller, Brigitte
目的：本研究的目的是评估急性心肺衰竭后机械循环支持的长期幸存者的健康相关生活质量。设计：前瞻性随访研究。环境：先天性心脏病和儿科心脏病中心的单一机构。患者：2001年至2012年在我院接受58次机械循环支持治疗的50例患者。中位年龄为2（0 ~ 213）个月，中位支持时间为5（1 ~ 234）天。适应症组：1)低心排血量体外生命支持30例（52%）；2)体外心肺复苏：13例（22%）；3)体外膜氧合治疗急性呼吸窘迫综合征4例（7%）；4)心室辅助装置：11例（19%）。干预措施：根据年龄组使用标准化问卷测量与健康有关的生活质量，并由7岁以下儿童的父母代理或幸存者本人完成。测量和主要结果：50%的患者出院回家，22名长期幸存者（44%）进行了健康相关生活质量的前瞻性研究。中位随访时间为4.5（0.3-11.3）年。随访时的中位年龄为5岁（0.6-29岁）。19名长期幸存者填写了健康相关生活质量问卷，并分为三个年龄组：0-4岁（n = 7）：健康相关生活质量得分中位数为69（59-86）分；4-12岁（n = 7）：健康相关生活质量得分中位数为50（48-85）分；12岁以上（n = 5）：健康相关生活质量得分中位数为90（80-100）分。结论：父母报告的长期幸存者健康相关生活质量低于健康儿童。然而，本组12岁以上患者自我评估的健康相关生活质量与健康对照人群相当。
Objective: The objective of this study was to evaluate health-related quality of life in long-term survivors of mechanical circulatory support after acute cardiopulmonary failure.Design: Prospective follow-up study.Setting: Single-institutional in a center for congenital heart disease and pediatric cardiology.Patients: Fifty patients who underwent 58 mechanical circulatory support therapies in our institution from 2001 to 2012. Median age was 2 (0-213) months, and median supporting time was 5 (1-234) days. Indication groups: 1) extracorporeal life support in low cardiac output: 30 cases (52%); 2) extracorporeal cardiopulmonary resuscitation: 13 cases (22%); 3) extracorporeal membrane oxygenation in acute respiratory distress syndrome: four cases (7%); and 4) ventricular assist devices: 11 cases (19%).Interventions: Health-related quality of life was measured using standardized questionnaires according to the age group and completed by either parent proxies in children under 7 years old or the survivors themselves.Measurements and Main Results: Fifty percentage of the patients were discharged home, and 22 long-term survivors (44%) were studied prospectively for health-related quality of life. Median follow-up period was 4.5 (0.3-11.3) years. Median age at follow-up was 5 (0.6-29) years old. Nineteen long-term survivors filled in the health-related quality of life questionnaires and were classified into three age groups: 0-4 years (n = 7): median health-related quality of life score, 69 (59-86) points; 4-12 years (n = 7): median health-related quality of life score, 50 (48-85) points; older than 12 years (n = 5): median health-related quality of life score, 90 (80-100) points.Conclusion: Long-term survivors' health-related quality of life as reported by their parents is lower than that of healthy children. However, the self-assessed health-related quality of life of the patients older than 12 years in our group is comparable to a healthy control population.