Impaired glucose tolerance and abnormal movements in patients with schizophrenia.
Impaired glucose tolerance and abnormal movements in patients with schizophrenia.
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精神分裂症患者的糖耐量受损和运动异常。
DOI：
10.1176/ajp.156.4.640
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Andreasen,NC
中科院分区：
文献类型：
--
作者：
Schultz,SK;Arndt,S;Ho,BC;Oliver,SE;Andreasen,NC
糖尿病被认为是迟发性运动障碍的危险因素。作者研究了异常运动和糖代谢受损之间的关联，这往往先于发展明显的糖尿病，精神分裂症patients with schizophrenia. METHOD 21例DSM-IV精神分裂症患者接受抗精神病药物口服葡萄糖耐量试验，涉及系列葡萄糖和胰岛素水平。分析这些数值与异常不自主运动评分的关系，发现糖耐量减低患者的平均异常运动评分高于无糖耐量减低患者，但差异无统计学意义。然而，在作者控制空腹血糖水平后，空腹胰岛素水平的大小与异常运动之间存在关联。此外，空腹血糖水平预测异常运动后，作者控制年龄。CONCLUSIONSSHyperinsulinemia和高血糖与胰岛素抵抗可能潜在的迟发性运动障碍的发病机制。这项小型横断面研究的结果表明，可能存在的关系需要通过更大规模的纵向研究来澄清。
OBJECTIVEDiabetes mellitus has been implicated as a risk factor for tardive dyskinesia. The authors examined the association between abnormal movements and impaired glucose metabolism, which often precedes the development of overt diabetes, in patients with schizophrenia.METHODTwenty-one patients with DSM-IV schizophrenia receiving neuroleptic medication were given oral glucose tolerance tests involving serial glucose and insulin levels. These values were analyzed in relationship to abnormal involuntary movement ratings.RESULTSPatients with impaired glucose tolerance had higher mean abnormal movement scores than those without glucose intolerance, but this difference was not statistically significant. There was, however, an association between the magnitude of the fasting insulin level and abnormal movements after the authors controlled for fasting glucose level. Additionally, the fasting glucose level predicted abnormal movements after the authors controlled for age.CONCLUSIONSHyperinsulinemia and hyperglycemia associated with insulin resistance may potentially contribute to the pathogenesis of tardive dyskinesia. Findings from this small cross-sectional study suggest a possible relationship that requires clarification through larger, longitudinal studies.