Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry
Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry
复制标题
20(S)-人参皂苷 Rg3 对链脲佐菌素诱导的实验性 2 型糖尿病大鼠的影响：通过快速分辨率液相色谱/质谱法进行的尿代谢组学研究。
DOI：
10.1002/rcm.6392
复制
发表时间：
2012-12-15
影响因子：
2
通讯作者：
Liu, Shu-Ying
中科院分区：
文献类型：
--
作者：
Niu, Jun;Pi, Zi-Feng;Liu, Shu-Ying
理由
20（S）-人参皂苷Rg 3是人参的有效成分。已知20（S）-TRg 3在体内对高血糖症、肥胖症和糖尿病具有保护作用，但这些作用的确切机制尚未完全阐明。
方法
建立了基于快速分辨液相色谱/质谱（RRLC/MS）的尿代谢组学方法，研究20（S）-β-Rg 3对2型糖尿病大鼠的影响。
结果
通过多变量统计分析，在2型糖尿病大鼠和用20（S）-β-Rg 3治疗的那些之间实现了清楚的分离。发现并鉴定了六种潜在的生物标志物。
结论
提示20（S）-β-Rg 3对2型糖尿病的作用机制可能与调节核酸代谢、能量代谢和肠道植物群代谢有关。
RATIONALE
20(S)-ginsenoside Rg3 is an active component of Panax ginseng. It is known that 20(S)-ginsenoside Rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated.
METHODS
A urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of 20(S)-ginsenoside Rg3 on type 2 diabetic rats.
RESULTS
With multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(S)-ginsenoside Rg3 was achieved. Six potential biomarkers were found and identified.
CONCLUSIONS
This work shows that the mechanism of the effect of 20(S)-ginsenoside Rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism.