Relationship between weight loss and parameters of skeletal muscle function in patients with advanced cancer and fatigue
Relationship between weight loss and parameters of skeletal muscle function in patients with advanced cancer and fatigue
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DOI：
10.1007/s00520-016-3236-9
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发表时间：
2016-09-01
影响因子：
3.1
通讯作者：
Navigante, A.
中科院分区：
文献类型：
--
作者：
Cresta Morgado, P.;Giorlando, A.;Navigante, A.
本研究旨在探讨重度减重对晚期癌症疲劳患者骨骼肌功能参数的影响，并对两组晚期癌症疲劳患者（疲劳数字量表（FNS）a/1000 yen 4）进行横断面比较研究。A组（n = 27）在过去6个月内体重减轻5%，B组（n = 22）体重未减轻。通过握力技术检查肌肉力量，通过生物阻抗分析（BIA）测量身体成分，血红蛋白、白蛋白、乳酸脱氢酶（LDH）、C反应蛋白（CRP）、尿肌酐和FNS值。这些变量在两组之间进行比较，并且在每一group.here中，关于双臂之间的肌肉力量参数没有差异。A组的CRP a值为77%，而B组为38.5%（p = 0.004）。A臂显示出比B臂更高的体细胞质量百分比（%）（p = 0.005）。与B组相比，A组的脂肪量百分比（%FM）也较低（p = 0.014）。A组的FNS较高（中位数7 vs 5; p = 0.047）。肌肉力量各变量间均呈显著正相关。在A组中，BMI与CRP呈显著负相关（p = 0.021），在本研究中，显著体重减轻和高CRP对骨骼肌功能参数无影响。我们认为，进一步的研究应该是必要的，最好是纵向设计，以评估这些发现。
This study aims to determine the influence of significant weight loss on parameters of skeletal muscle function in a population of advanced cancer patients with fatigue.A cross-sectional and comparative study was designed between two arms of advanced cancer patients with fatigue (fatigue numeral scale (FNS) a parts per thousand yen4). A arm (n = 27) with a parts per thousand yen5 % weight loss in the last 6 months, and B arm (n = 22) without weight loss. Muscle strength was examined by hand grip technique and measurements of body composition by bioimpedance analysis (BIA), values of hemoglobin, albumin, lactic dehydrogenase (LDH), c-reactive protein (CRP), urine creatinine, and FNS. These variables were compared between both groups and correlated within each group.here were no differences concerning parameters of muscle strength between both arms. A arm had values of CRP a parts per thousand yen10 ug/dl in 77 % compared with 38.5 % of B arm (p = 0.004). A arm showed a higher percentage of body cell mass (%BCM) than B arm (p = 0.005). The A arm also showed a lower percentage of fat mass (%FM) (p = 0.014) when compared to the B arm. FNS was higher in A arm (median 7 vs 5; p = 0.047). All the variables of muscle strength had a significant positive correlation. In A arm, BCM had a negative significant correlation with CRP (p = 0.021).In this study, significant weight loss and high CRP did not have influence on parameters of skeletal muscular function. We consider that further studies should be necessary, preferably with longitudinal designs to evaluate these findings.