Development and Expression of Maternal Behavior in Naive Female C57BL/6 Mice
Development and Expression of Maternal Behavior in Naive Female C57BL/6 Mice
复制标题
DOI：
10.1002/dev.21276
复制
发表时间：
2015-03-01
影响因子：
2.2
通讯作者：
Olazabal, Daniel E.
中科院分区：
文献类型：
--
作者：
Alsina-Llanes, Marcela;De Brun, Victoria;Olazabal, Daniel E.
幼稚的雌性老鼠通常被描述为自发的母鼠。我们研究了20-22、30-35、60-65日龄幼龄雌性小鼠(C57BL/6)需要暴露于幼鼠多少次(15分钟比1小时)才能诱导完全母性行为(FMB)，以及与临产母亲和新生兄弟姐妹同居如何促进青少年母性行为(MB)。只有20%的成年犬在第一次接触幼崽后立即出现了FMB。在青少年、青少年和成人中，不完全MB的比例分别为11%、20%和30%。360分钟暴露在幼崽身上，在所有成年受试者中都会诱发FMB。所有没有接触到兄弟姐妹和母体体液的幼稚幼崽都没有表现出母性行为。相比之下，在第二胎分娩期间出现在家中的幼崽中，超过一半的幼崽在单独测试时显示出不完整的MB(34.5%)或FMB(21.5%)，这些幼崽被关在新的笼子里。这项研究表明，大多数成年雌性小鼠不是自发的母体，而是逐渐致敏的。此外，幼稚的幼崽可能会被抑制或没有动力表现出MB，但如果以前暴露在新生儿兄弟姐妹和母体液体中，则会对幼崽表现出成人式的行为。(C)2015 Wiley期刊，Inc.开发心理学57：189-200,2015。
Naive female mice are usually described as spontaneously maternal. We investigated how many exposures to pups (15min vs. 1hr) were needed to induce full maternal behavior (FMB) in 20-22, 30-35, 60-65-days-old naive female mice (C57BL/6), and how cohabitation with the parturient mother and newborn siblings facilitated juvenile maternal behavior (MB). Only 20% of the adults displayed FMB immediately after the first exposure to pups. Incomplete MB was present in 11%, 20%, and 30% of juveniles, adolescents and adults, respectively. Three-sixty minute exposures to pups induced FMB in all adult subjects. All naive juveniles that were not exposed to their siblings and maternal fluids failed to show maternal behavior. In contrast, more than half of the juveniles present at their homecage during delivery of a second litter showed incomplete MB (34.5%) or FMB (21.5%) when tested individually housed in a novel cage. This study suggests that most adult female mice are not spontaneously maternal but gradually sensitized. Besides, naive juveniles could be inhibited or not motivated to show MB, but display adult-like behavior toward pups if previously exposed to newborn siblings and maternal fluids. (c) 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 189-200, 2015.