Adrenal secretion of epinephrine after stimulation of trigeminal nucleus caudalis depends on stimulus pattern.
Adrenal secretion of epinephrine after stimulation of trigeminal nucleus caudalis depends on stimulus pattern.
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刺激三叉神经尾核后肾上腺分泌的肾上腺素取决于刺激模式。
DOI：
10.1159/000124703
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发表时间：
1987
影响因子：
4.1
通讯作者：
Gann,DS
中科院分区：
文献类型：
--
作者：
Bereiter,DA;Engeland,WC;Gann,DS
通过对麻醉猫的肾上腺静脉血取样，将刺激三叉神经尾核（Vc）后的肾上腺儿茶酚胺分泌与更多腹外侧脑干区域（VLM）引起的儿茶酚胺分泌进行比较。通过在每个电极部位提供相同数量（15 秒内 300 个脉冲）的连续模式和突发模式脉冲序列电刺激（75 µA，0.2 ms）来评估刺激模式对儿茶酚胺分泌的影响。 Vc 的突发模式刺激后 1 分钟，肾上腺素分泌迅速增加，而连续模式刺激则没有一致的效果。 VLM 部位的突发模式刺激导致肾上腺素分泌小幅减少，而连续模式刺激则没有显着影响。无论刺激模式如何，Vc 或 VLM 刺激后肾上腺去甲肾上腺素均等增加。肾上腺儿茶酚胺分泌反应不能用肾上腺静脉血浆流量或动脉压的瞬时诱发变化来解释。数据表明，Vc 的刺激会引起肾上腺素分泌的模式依赖性增加，而去甲肾上腺素分泌的增加在突发或连续模式刺激后是相等的。此外，仅通过测量肾上腺素分泌不能充分评估猫中短暂神经刺激的肾上腺激活，因为刺激许多腹外侧脑干部位导致去甲肾上腺素分泌显着增加，而肾上腺素分泌没有相应增加。
Adrenal catecholamine secretion after stimulation of trigeminal nucleus caudalis (Vc) was compared to that evoked from more ventrolateral brain stem areas (VLM) by sampling adrenal venous blood in anesthetized cats. The effect of stimulus pattern on catecholamine secretion was assessed by presenting an equal number (300 pulses over 15 s) of electrical stimuli (75 µA, 0.2 ms) as a continuous pattern and as a burst pattern pulse train at each electrode site. Epinephrine secretion increased promptly by 1 min after burst pattern stimulation of Vc, whereas continuous pattern stimuli had no consistent effect. Burst pattern stimulation of VLM sites caused a small decrease in epinephrine secretion, whereas continuous pattern stimuli had no significant effect. Adrenal norepinephrine increased equally after Vc or VLM stimulation regardless of stimulus pattern. The adrenal catecholamine secretory responses could not be explained by the transient evoked changes in adrenal venous plasma flow or arterial pressure. The data indicate that stimulation of Vc evokes a pattern-dependent increase in epinephrine secretion, whereas the increase in norepinephrine secretion is equal after burst or continuous pattern stimuli. Further, adrenal activation by brief neural stimuli cannot be assessed adequately in the cat by measuring epinephrine secretion alone, since stimulation of many ventrolateral brain stem sites caused a significant increase in norepinephrine secretion with no corresponding increase in epinephrine secretion.