Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial
Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial
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DOI：
10.1371/journal.pmed.1002388
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发表时间：
2017-09-01
期刊：
影响因子：
15.8
通讯作者：
Saville, Marion
中科院分区：
文献类型：
--
作者：
Canfell, Karen;Caruana, Michael;Saville, Marion
背景：与细胞学检查相比，在宫颈筛查中使用原发性人乳头瘤病毒（HPV）检测可增加高级别宫颈上皮内肿瘤病变和浸润性癌（宫颈上皮内瘤变2+级[CIN2+]）的检出率，但尚未在先前接种HPV疫苗的人群中进行评估。我们的目的是评估澳大利亚hpv疫苗接种人群（截至2014年）中hpv筛查与细胞学筛查女性的阴道镜转诊和CIN2+检出率
BackgroundUsing primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women