Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis
Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis
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DOI：
10.1016/j.ejphar.2006.01.015
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发表时间：
2006-03-18
影响因子：
5
通讯作者：
Lee, SM
中科院分区：
文献类型：
--
作者：
Kim, JY;Lee, SM
研究了维生素C和E对多微生物脓毒症患者肝微粒体细胞色素P450 （CYP）活性和基因表达的影响。结扎和穿刺后24 h血清转氨酶和脂质过氧化水平升高，维生素C和e可减弱这种升高，败血症动物肝脏还原性谷胱甘肽浓度降低，维生素C可抑制这种升高，结扎和穿刺后CYP1A1和CYP2E1活性和mRNA表达均降低。维生素C和E可以防止盲肠结扎和穿刺后肝脏中CYP1A2活性的下降。我们的研究结果表明，维生素C和E可以改善肝脏药物代谢功能障碍，正如脓毒症期间CYP异构体的异常所表明的那样，这种保护在很大程度上是由氧化应激和脂质过氧化的减少引起的。(c) 2006 Elsevier B.V.版权所有
The effect of vitamins C and E on the activity and gene expression of hepatic microsomal cytochrome P450 (CYP) during polymicrobial sepsis was studied. The serum aminotransferase and lipid peroxidation levels increased 24 h after the cecal ligation and puncture, and this increase was attenuated by vitamins C and E. The hepatic concentrations of the reduced glutathione decreased in the septic animals, which was inhibited by vitamin C. Both the activities and mRNA expression of CYP1A1 and CYP2E1 decreased after cecal ligation and puncture, which was prevented by vitamins C and E. The decrease in CYP1A2 activity in the liver from cecal ligation and puncture was prevented by vitamins C and E. Our findings suggest that vitamins C and E improve hepatic drug metabolizing dysfunction as indicated by abnormalities in CYP isoforms during sepsis, and this protection is, in major part, caused by decreased oxidant stress and lipid peroxidation. (c) 2006 Elsevier B.V. All rights reserved.