Characterization and Function of Circular RNAs in Plants

Characterization and Function of Circular RNAs in Plants
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植物中环状 RNA 的表征和功能

DOI:
10.3389/fmolb.2020.00091
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发表时间:
2020-05
影响因子:
5
通讯作者:
Ming Chen
Ming Chen
中科院分区:
生物学3区
文献类型:
--
作者:
Peijing Zhang;Sida Li;Ming Chen

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CircRNA是在真核生物中广泛表达的共价闭环单链RNA分子。作为内源性ncRNA家族的重要成员,circRNA与多种生物学过程相关,可以调节转录、选择性剪接以及与miRNA或蛋白质相互作用。与动物中的大量进展相比,植物中circRNA的研究正在迅速兴起。植物circRNA的数据库和分析工具正在不断发展。在植物中发现了大量的circRNA,并证实其在植物生长、发育和逆境应答中起着重要的调控作用。本文综述了植物circRNA的生物起源、特征、生物信息学资源和生物学功能,并与动物相关研究结果进行了比较,总结了其独特的环化特征和差异表达模式。
CircRNAs are covalently closed-loop single-stranded RNA molecules ubiquitously expressing in eukaryotes. As an important member of the endogenous ncRNA family, circRNAs are associated with diverse biological processes and can regulate transcription, modulate alternative splicing, and interact with miRNAs or proteins. Compared to abundant advances in animals, studies of circRNAs in plants are rapidly emerging. The databases and analysis tools for plant circRNAs are constantly being developed. Large numbers of circRNAs have been identified and characterized in plants and proved to play regulatory roles in plant growth, development, and stress responses. Here, we review the biogenesis, characteristics, bioinformatics resources, and biological functions of plant circRNAs, and summarize the distinct circularization features and differentially expression patterns comparison with animal-related results.
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