Autonomous Pathway: FLOWERING LOCUS C Repression through an Antisense-Mediated Chromatin-Silencing Mechanism
Autonomous Pathway: FLOWERING LOCUS C Repression through an Antisense-Mediated Chromatin-Silencing Mechanism
复制标题
自主途径：通过反义介导的染色质沉默机制抑制开花位点 C
DOI：
10.1104/pp.19.01009
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发表时间：
2020-01-01
期刊：
影响因子：
7.4
通讯作者：
Deati, Caroline
中科院分区：
文献类型：
--
作者：
Wu, Zhe;Fang, Xiaofeng;Deati, Caroline
开花时间对于植物繁殖成功至关重要，因此受到内源和外源信号的严格调控。在夏季一年生拟南芥 (Arabidopsis thaliana) 种质中，如 Columbia-0，通过抑制花抑制基因 FLOWERING LOCUS C (FLC) 促进快速开花。这是通过自主途径的活性实现的，自主途径是一组具有多种功能的蛋白质，包括 RNA 3' 末端加工因子、剪接体成分、转录延伸因子和染色质修饰剂。这些因子在 FLC 位点发挥作用，将反义长非编码 RNA（称为 COOLAIR）的替代处理与影响转录输出的抑制性染色质环境的传递联系起来。转录输出反馈影响染色质环境，强化和稳定该状态。这篇综述总结了我们目前对自主途径的了解，并将其与其他生物体中类似的共转录机制进行了比较。
The timing of flowering is vital for plant reproductive success and is therefore tightly regulated by endogenous and exogenous cues. In summer annual Arabidopsis (Arabidopsis thaliana) accessions, like Columbia-0, rapid flowering is promoted by repression of the floral repressor FLOWERING LOCUS C (FLC). This is through the activity of the autonomous pathway, a group of proteins with diverse functions including RNA 3'-end processing factors, spliceosome components, a transcription elongation factor, and chromatin modifiers. These factors function at the FLC locus linking alternative processing of an antisense long noncoding RNA, called COOLAIR, with delivery of a repressive chromatin environment that affects the transcriptional output. The transcriptional output feeds back to influence the chromatin environment, reinforcing and stabilizing that state. This review summarizes our current knowledge of the autonomous pathway and compares it with similar cotranscriptional mechanisms in other organisms.