A CORTICO-SUBCORTICAL MODEL FOR GENERATION OF SPATIALLY ACCURATE SEQUENTIAL SACCADES
A CORTICO-SUBCORTICAL MODEL FOR GENERATION OF SPATIALLY ACCURATE SEQUENTIAL SACCADES
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DOI：
10.1093/cercor/2.2.153
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发表时间：
1992-03-01
期刊：
影响因子：
3.7
通讯作者：
ARBIB, MA
中科院分区：
文献类型：
--
作者：
DOMINEY, PF;ARBIB, MA
本文提供了一个系统的框架，分析皮层和皮层下的相互作用，在控制扫视眼球运动，这个模型的一个主要论点是，通过多个投影之间的大脑区域，直到他们最终转化为一个时间模式的活动，驱动眼睛的目标，扫视方向和幅度的地形被保存。对视觉和记忆目标的随意扫视的控制是根据后顶叶皮层、额叶眼区、基底神经节（尾状核和黑质）、上级丘、内侧背丘脑和脑干的扫视发生器之间的相互作用来建模的。相互作用包括地形抑制性投射对眼动运动误差图的调制，眼跳运动误差图中空间目标表征的动态重新映射，以及体现空间记忆的持续神经活动。在我们的神经模拟语言中实现的这些机制的模型模拟了文献中描述的行为和神经活动，并提出了新的实验。
This article provides a systems framework for the analysis of cortical and subcortical interactions in the control of saccadic eye movements, A major thesis of this model is that a topography of saccade direction and amplitude is preserved through multiple projections between brain regions until they are finally transformed into a temporal pattern of activity that drives the eyes to the target. The control of voluntary saccades to visual and remembered targets is modeled in terms of interactions between posterior parietal cortex, frontal eye fields, the basal ganglia (caudate and substantia nigra), superior colliculus, mediodorsal thalamus, and the saccade generator of the brainstem. Interactions include the modulation of eye movement motor error maps by topographic inhibitory projections, dynamic remapping of spatial target representations in saccade motor error maps, and sustained neural activity that embodies spatial memory. Models of these mechanisms implemented in our Neural Simulation Language simulate behavior and neural activity described in the literature, and suggest new experiments.