Relationship between the activity of precentral neurones during active and passive movements in conscious monkeys
Relationship between the activity of precentral neurones during active and passive movements in conscious monkeys
复制标题
清醒猴主动运动和被动运动时中央前神经元活动的关系
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
Robert Porter
中科院分区：
文献类型：
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作者：
Roger Lemon;J. Hanby;Robert Porter
有意识的猴子的中央前皮层的神经元进行了记录，这些猴子为了食物奖励而执行刻板的运动任务。当猴子进行各种运动以收集放置在多个不同位置的食物奖励时，研究了每个运动相关神经元的活动。在 362 个与任务相关的神经元中，176 个神经元表现出对其放电频率的明确调节，这可能与一个关节或多个相关手指关节的特定随意运动的表现有关。因此，这些神经元可以被分类为具有与肩、肘、腕、手或手指的特定随意运动相关的放电。然后，当动物按照训练的方式放松地坐着时，通过对手臂皮肤、关节和肌肉的自然刺激来检查相同神经元的反应。 176 个神经元中有 149 个对来自特定外周区域的传入输入做出反应。 176 个神经元中有 130 个具有来自解剖学上与参与特定主动运动的关节密切相关的区域的传入输入，而神经元的自然放电与该特定主动运动明显相关。对表现出给定输入和输出关联的运动皮层细胞的解剖分布的分析表明，并非受限局部神经元群的所有成员都共享相同的外周区域。当他们这样做时，与细胞放电相关的区域的运动方向在主动和被动条件下可能相同或相反。此外，并非所有与关节主动运动有特定关联的神经元以及来自同一区域的输入都聚集在运动皮层的一个受限局部区域中；共享这些输入/输出特性的组中的一些成员可能位于距主聚集体最远 5 毫米的地方。尝试区分中央前回的接收神经元和输出神经元的特性。
Recordings have been made from neurones in the precentral cortex of conscious monkeys carrying out a stereotyped movement task for food rewards. The activity of each movement related neurone was investigated while the monkey performed a wide variety of movements in order to collect the food reward placed in a number of different positions. Of 362 task-related neurones, 176 neurones showed definite modulation of their discharge frequency which could be related to the performance of specific voluntary movements about one joint, or at a number of associated digit joints. These neurones could therefore be classified to have discharges associated with particular voluntary movements of shoulder, elbow, wrist, hand or fingers. The responses of the same neurones were then examined with natural stimulation of the skin, joints and muscles of the arm while the animal sat relaxed as it had been trained to do. 149 of the 176 neurones responded to afferent input from particular peripheral territories. 130 of the 176 neurones had afferent inputs from zones which were anatomically closely related to the joint involved in the specific active movement with which the neurone’s natural discharges were clearly associated. An analysis of the anatomical distribution in the motor cortex of the cells exhibiting given input and output associations revealed that not all the members of a restricted local population of neurones shared the same peripheral territory. When they did, the direction of movement of that territory which was associated with discharge of the cell could be the same or opposite under active and passive conditions. Moreover, not all the neurones with a particular association with active movement of a joint and an input from that same region were aggregated in the one restricted local area of the motor cortex; some members of the group sharing these input/output characteristics could be situated up to 5 mm from the main aggregation. An attempt is made to distinguish between the properties of receiving neurones and output neurones of the precentral gyrus.