IDENTIFICATION OF A RETICULOENDOTHELIAL STIMULATING AGENT IN ZYMOSAN
IDENTIFICATION OF A RETICULOENDOTHELIAL STIMULATING AGENT IN ZYMOSAN
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DOI：
10.1152/ajplegacy.1961.200.2.297
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发表时间：
1961-01-01
影响因子：
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通讯作者：
DILUZIO, NR
中科院分区：
文献类型：
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作者：
RIGGI, SJ;DILUZIO, NR
网状内皮系统（RES）的功能活性，确定由胶体碳的血管内清除，和诱导RE增生的程度进行了研究后，静脉注射酵母多糖的各种成分。从酵母细胞壁中容易提取的脂质成分是无活性的，多糖甘露聚糖也是如此。刺激活性仍然存在于酵母多糖残留物去除后的自由和结合的脂质。给予来源于酵母或其细胞壁的葡聚糖导致显著的RE激活和诱导增生，证明其是活性RE刺激剂。讨论了葡聚糖的化学结构与其诱导RE功能亢进和增生能力的关系。
The functional activity of the reticuloendothelial system (RES), as determined by the intra-vascular clearance of colloidal carbon, and the degree of induced RE hyperplasia were studied following the intravenous injection of various constituents of zymosan. The readily extractable lipid component from the yeast cell wall was inactive, as was the polysaccharide, mannan. Stimulatory activity was still present in the zymosan residue after removal of free and bound lipids. The administration of glucan derived either from yeast, or its cell wall, resulted in marked RE activation and induced hyperplasia, demonstrating it to be the active RE stimulating agent. The relationship of glucan''s chemical structure to its ability to induce RE hyperfunction and hyperplasia is discussed.