Effects of alcohol on autonomic responses and thermal sensation during cold exposure in humans.
Effects of alcohol on autonomic responses and thermal sensation during cold exposure in humans.
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DOI：
10.1016/j.alcohol.2008.01.006
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发表时间：
2008-05
期刊：
影响因子：
2.3
通讯作者：
T. Yoda;L. Crawshaw;Kumiko Saito;Mayumi Nakamura;K. Nagashima;K. Kanosue
中科院分区：
文献类型：
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作者：
T. Yoda;L. Crawshaw;Kumiko Saito;Mayumi Nakamura;K. Nagashima;K. Kanosue
我们研究了酒精对人体冷暴露期间体温调节反应和热感觉的影响。8名健康男性，平均年龄(22.3±0.7)岁。每个受试者在18°C的室温下进行两次实验，在30分钟的休息时间后，受试者饮用15%的酒精，剂量为0.36g/kg体重(酒精阶段)或等量的蒸馏水(对照组)，并保持坐姿60min。平均皮肤温度继续下降，在对照组和饮酒组相似。酒精组的代谢率较低，但这种差异不影响核心温度，酒精组和对照组的核心温度以相似的方式下降(从36.9±0.1℃降至36.6±0.1℃)。在对照组中，全身的冷感和热感依次增强，而饮酒后这两种感觉都大大减弱。在之前的一项研究中，我们在高温下进行了研究，使用类似的方案，酒精对所有自主和感知的热损失效应器产生了明确的、协调的影响。在目前的研究中，与在高温下的反应相比，饮酒后自主神经效应器反应的变化较小，但感觉温度和热不适的变化增加。总体而言，我们的结果表明，尽管酒精在寒冷和炎热中影响体温调节，但影响的细节方面非常不同。
We investigated the effects of alcohol on thermoregulatory responses and thermal sensations during cold exposure in humans. Eight healthy men (mean age 22.3±0.7year) participated in this study. Experiments were conducted twice for each subject at a room temperature of 18°C. After a 30-min resting period, the subject drank either 15% alcohol at a dose of 0.36g/kg body weight (alcohol session) or an equal volume of distilled water (control session), and remained in a sitting position for another 60min. Mean skin temperature continued to decrease and was similar in control and alcohol sessions. Metabolic rate was lower in the alcohol session, but the difference did not affect core temperature, which decreased in a similar manner in both alcohol and control sessions (from 36.9±0.1°C to 36.6±0.1°C). Whole body sensations of cold and thermal discomfort became successively stronger in the control session, whereas these sensations were both greatly diminished after drinking alcohol. In a previous study, we performed in the heat, using a similar protocol, alcohol produced a definite, coordinated effect on all autonomic and sentient heat loss effectors. In the current study in the cold, as compared to responses in the heat, alcohol intake was followed by lesser alterations in autonomic effector responses, but increased changes in sensations of temperature and thermal discomfort. Overall, our results indicate that although alcohol influences thermoregulation in the cold as well as in the heat, detailed aspects of the influence are quite different.