Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.
Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.
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DOI：
10.1007/s11033-021-06740-z
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发表时间：
2021-12
影响因子：
2.8
通讯作者：
Ganguly NK
中科院分区：
文献类型：
--
作者：
Rana R;Sharma S;Ganguly NK
脑膜瘤发生于脑膜，是各种类型的脑肿瘤之一。其他的是，星形细胞瘤起源于星形胶质细胞，少突胶质细胞瘤起源于少突胶质细胞，室管膜瘤起源于室管膜细胞和髓母细胞瘤起源于神经元。目前对脑膜瘤的分子生物学、遗传学和表观遗传学的认识还不够。因此，深入了解脑膜瘤的形成和发展机制，对于脑膜瘤的治疗和管理是十分必要的。I级脑膜瘤主要分为I级、II级和III级。脑膜瘤可以是无痛的，生长缓慢的，也可以是侵袭性的和转移性的，可以复发。与侵袭性脑膜瘤相比，I级脑膜瘤可以通过手术切除，侵袭性脑膜瘤复发的可能性很高。这种复发的特性是高发病率和死亡率的原因。脑膜瘤主要分为I级、II级、III级三类。蛋白质生物标志物被认为是脑膜瘤诊断的有希望的候选者。对蛋白质差异表达的各种研究表明，EGFR、NEK 9、EPS812、CKAP 4、SET和STAT 2在所有三个级别的脑膜瘤中的表达增加。此外，一些蛋白质如HK2在II级和III级脑膜瘤中比在I级脑膜瘤中过表达。在不同级别脑膜瘤细胞外囊泡上发现的蛋白质标记物可以起到相同的作用。对任何类型的体液样本（如血液，泪液，唾液，尿液等）进行的测试，用于识别循环癌细胞或DNA和细胞外囊泡，以帮助检测癌症的早期阶段，被称为液体活检。与液体活检相比，固体活检有几个局限性。这是因为在液体活检的情况下可以容易地收集和研究样本。外泌体与液体活检相关，因此为更好地诊断、预后和治疗任何类型的癌症（包括脑膜瘤）提供了平台。外泌体四跨膜蛋白是外泌体生物标志物的重要实例。四跨膜蛋白网络是连接各种蛋白质进行信号转导的分子支架。本研究通过对脑膜瘤细胞外囊泡蛋白及其不同级别的表达谱的正确认识，有助于更好地了解脑膜瘤的发病机制、诊断、预后和治疗。除了使用这些蛋白质作为生物标志物之外，还讨论了外来体在目前可用的治疗方法中的作用。
Meningioma arising from meninges is one among the various types of brain tumors. Others are, astrocytomas originating from astrocyte, oligodendrogliomas originating from oligodendrocyte, Ependymomas originating from ependymal cells and medulloblastomas originating from neurons. Current knowledge of molecular biology, genetics and epigenetics of meningioma is not sufficient. Therefore, In depth understanding of the mechanism of meningioma formation and progression is needed for its treatment and management. Grade I Grade I meningiomas are majorly classified as grade I, grade II and grade III. Meningioma can be indolent, slow growing or can be invasive and metastatic which can recurre. Grade I meningioma can be removed by surgery in comparison to invasive meningioma which may recurre with high propensity. This property of recurrence is responsible for high morbidity and mortality. Meningioma are majorly classified into three classes namely grade I, grade II, grade III. Protein biomarkers are considered as promising candidates for the diagnosis of meningioma. Various studies done on differential expression of proteins have shown increased expression of EGFR, NEK9, EPS812, CKAP4, SET and STAT2, in all the three grades of meningioma. Additionally, some proteins like HK2 are overexpressed in grade II and grade III meningioma than in grade I meningioma. Protein Markers, found on extracellular vesicles of different grades of meningioma can serve the same purpose. A test done on a sample of any kind of body fluid like blood, tear, saliva, urine etc. for recognizing the circulating cancer cells or DNA and extracellular vesicles released from them to help detecting the early stage of cancer is known as liquid biopsy. Solid biopsy has several limitations as compared to liquid biopsy. This is because the samples can be easily collected and studied in case of liquid biopsy. Exosomes are related with liquid biopsy and hence provide platform for better diagnosis, prognosis and treatment of any type of cancer including meningioma. Exosomal tetraspanin are important example of exosomal biomarkers. The tetraspanin network is a molecular scaffold which connects various proteins for signal transduction. This study tells about the utility of proper knowledge of extracellular vesicle proteins and their profiles in different grades, which can help in better understanding of pathogenesis, diagnosis, prognosis and treatment of meningioma. In Addition to use of these proteins as biomarkers, role of exosomes in currently available therapeutic approaches has been discussed.
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影响因子：
16
作者：
Aspe JR;Diaz Osterman CJ;Jutzy JM;Deshields S;Whang S;Wall NR
通讯作者：
Wall NR
影响因子：
16
作者：
Bijnsdorp IV;Geldof AA;Lavaei M;Piersma SR;van Moorselaar RJ;Jimenez CR
通讯作者：
Jimenez CR
影响因子：
4.1
作者：
Barthelemy, Ernest Joseph;Sarkiss, Christopher A.;Shrivastava, Raj K.
通讯作者：
Shrivastava, Raj K.
DOI：
10.1126/science.1233009
发表时间：
2013-03-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Clark VE;Erson-Omay EZ;Serin A;Yin J;Cotney J;Ozduman K;Avşar T;Li J;Murray PB;Henegariu O;Yilmaz S;Günel JM;Carrión-Grant G;Yilmaz B;Grady C;Tanrikulu B;Bakircioğlu M;Kaymakçalan H;Caglayan AO;Sencar L;Ceyhun E;Atik AF;Bayri Y;Bai H;Kolb LE;Hebert RM;Omay SB;Mishra-Gorur K;Choi M;Overton JD;Holland EC;Mane S;State MW;Bilgüvar K;Baehring JM;Gutin PH;Piepmeier JM;Vortmeyer A;Brennan CW;Pamir MN;Kiliç T;Lifton RP;Noonan JP;Yasuno K;Günel M
通讯作者：
Günel M
影响因子：
11.2
作者：
Di Vizio D;Kim J;Hager MH;Morello M;Yang W;Lafargue CJ;True LD;Rubin MA;Adam RM;Beroukhim R;Demichelis F;Freeman MR
通讯作者：
Freeman MR