Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases.
Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases.
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DOI：
10.3390/ijms232213763
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发表时间：
2022-11-09
影响因子：
5.6
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中科院分区：
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热休克转录因子（HSF，即heat shock transcription factor 或 heat shock factor）是作为热休克反应不可或缺的转录因子而被发现的。尽管在哺乳动物中发现了4种经典的热休克转录因子，且在1991年克隆出了两种主要的热休克转录因子HSF1和HSF2，但由于HSF1可通过诱导多种热休克蛋白（HSP）的表达引发热休克反应，因此只有HSF1得到了深入研究。另一方面，HSF2在一段时间内未得到充分研究，这可能是因为对HSF2本身的认识不足。自21世纪初以来，HSF2的研究取得了进展，其许多重要生物学功能得以揭示。例如，HSF2在神经系统保护、炎症、有丝分裂和减数分裂维持以及癌细胞存活与死亡中的作用已逐渐明晰。然而，我们认为HSF2与多种因素相关这一事实尚未得到广泛认可，因此HSF2的生物学意义被低估了。我们强烈希望通过这篇综述，向广泛研究领域的研究人员和读者广泛传达HSF2的重要性。此外，我们也希望众多读者能对本文综述中所总结的HSF2作为活性转录因子发挥作用的分子机制以及细胞周期进程中HSF2的基因书签机制产生浓厚兴趣。
HSF (heat shock transcription factor or heat shock factor) was discovered as a transcription factor indispensable for heat shock response. Although four classical HSFs were discovered in mammals and two major HSFs, HSF1 and HSF2, were cloned in the same year of 1991, only HSF1 was intensively studied because HSF1 can give rise to heat shock response through the induction of various HSPs’ expression. On the other hand, HSF2 was not well studied for some time, which was probably due to an underestimate of HSF2 itself. Since the beginning of the 21st century, HSF2 research has progressed and many biologically significant functions of HSF2 have been revealed. For example, the roles of HSF2 in nervous system protection, inflammation, maintenance of mitosis and meiosis, and cancer cell survival and death have been gradually unveiled. However, we feel that the fact HSF2 has a relationship with various factors is not yet widely recognized; therefore, the biological significance of HSF2 has been underestimated. We strongly hope to widely communicate the significance of HSF2 to researchers and readers in broad research fields through this review. In addition, we also hope that many readers will have great interest in the molecular mechanism in which HSF2 acts as an active transcription factor and gene bookmarking mechanism of HSF2 during cell cycle progression, as is summarized in this review.