Low B-cell and monocyte counts on day 80 are associated with high infection rates between days 100 and 365 after allogeneic marrow transplantation
Low B-cell and monocyte counts on day 80 are associated with high infection rates between days 100 and 365 after allogeneic marrow transplantation
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DOI：
10.1182/blood.v96.9.3290.h8003290_3290_3293
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发表时间：
2000-11-01
期刊：
影响因子：
20.3
通讯作者：
Maloney, D
中科院分区：
文献类型：
--
作者：
Storek, J;Espino, G;Maloney, D
为了确定哪种单核细胞亚群缺陷在骨髓移植受者对感染的易感性中起作用，在第80天前瞻性地测定了108名患者的单核细胞亚群计数，由对亚群计数不知情的研究者记录在第100天和第365天之间发生的感染。在单变量分析中，以下子集的计数显示与感染率显著负相关：总细胞、IgD（+）B细胞、IgD（-）B细胞、总CD 4 T细胞、CD 28（+）CD 4 T细胞、CD 28（-）CD 4 T细胞、CD 45 RA（低/-）CD 4 T细胞和单核细胞。在多变量分析中，以下亚群的计数与感染率呈显著负相关：总B细胞（P = .0004）和单核细胞（P = .009），CD 28（-）CD 8 T细胞计数与感染率无相关性。总之，移植后晚期患者对感染的易感性可能部分归因于B细胞和单核细胞的缓慢重建，（C）2000，美国血液学会。
To ascertain which mononuclear cell subset deficiency plays a role in the marrow transplant recipient's susceptibility to infections, mononuclear cell subset counts were prospectively determined in 108 patients on day 80, infections occurring between day 100 and 365 were recorded by an investigator blinded to the subset counts. In univariate analyses, the counts of the following subsets showed a significant inverse correlation with infection rates: totals cells, IgD(+) B cells, IgD(-) B cells, total CD4 T cells, CD28(+) CD4 T cells, CD28(-) CD4 T cells, CD45RA(low/-) CD4 T cells and monocytes. In multivariate analyses, the counts of the following subsets remained significantly inversely correlated with the infection rates: total B cells (P = .0004) and monocytes (P = .009), CD28(-) CD8 T-cell counts showed no correlation with infection rates. In conclusion, the susceptibility of patients to infections late posttransplant may be due in part to the slow reconstitution of B cells and monocytes, (C) 2000 by The American Society of Hematology.