Different composition and mitotic activity of the haemopoietic tissue in bone marrow, spleen and liver in chronic myeloid leukaemia.
Different composition and mitotic activity of the haemopoietic tissue in bone marrow, spleen and liver in chronic myeloid leukaemia.
复制标题
慢性粒细胞白血病骨髓、脾脏和肝脏造血组织的不同组成和有丝分裂活性。
作者：
U. Sjögren;L. Brandt
对15例初治慢性粒细胞白血病(CML)患者的骨髓、脾、肝抽吸物进行了分析。脾、肝中的红细胞比例高于骨髓。与骨髓相比，髓外部位嗜碱性白细胞的出现频率增加。在肝抽吸物中发现了相当多的淋巴细胞混合物。脾和肝中粒系和红系前体细胞的分裂指数低于骨髓。结果表明，慢性粒细胞白血病骨髓和髓外部位的造血组织成分和增殖活性不同。这种差异可能是由于造血细胞微环境的不同，或者是髓外有丝分裂活性低的细胞选择性聚集所致。由于CML的最终原始转化可能起源于骨髓外，因此对髓外造血组织的进一步研究可能是值得的。
Aspirates from bone marrow, spleen and liver were analyzed in 15 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythroblasts was higher in the spleen and liver than in the bone marrow. An increased frequency of basophilic leucocytes was recorded in the extramedullary sites compared to the bone marrow. In the liver aspirates a considerable admixture of lymphocytes was found. The mitotic indices of the granulopoietic and erythropoietic precursor cells were lower in the spleen and liver than in the bone marrow. The results indicate that the composition and proliferative activity of the haemopoietic tissue differ in bone marrow and extramedullary sites in CML. The discrepancies may be due to differences in the microenvironment for the haemopoietic cells or to a selective accumulation of cells with a low mitotic activity in extramedullary sites. Since the final blastic transformation of CML may originate outside the bone marrow, further studies of the extramedullary haemopoietic tissue may be worthwhile.