The contribution of HIV infection to intracranial arterial remodeling: a pilot study.
The contribution of HIV infection to intracranial arterial remodeling: a pilot study.
复制标题
DOI：
10.1111/j.1440-1789.2012.01358.x
复制
发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Marshall RS
中科院分区：
文献类型：
--
作者：
Gutierrez J;Elkind MS;Petito C;Chung DY;Dwork AJ;Marshall RS
Pathological arterial wall changes have been cited as potential mechanisms of cerebrovascular disease in the HIV population. We hypothesize that dilatation would be present in arterial walls of patients with HIV compared to controls. Fifty-one intracranial arteries, obtained from autopsies of five individuals with HIV infection and 13 without, were fixed, embedded, stained, and digitally photographed. Cross-sectional areas of intima, media, adventitia and lumen were measured by preset color thresholding. A measure of arterial remodeling was obtained by calculating the ratio between the lumen diameter and the thickness of the arterial wall. Higher numbers indicate arterial dilatation, while lower numbers indicate arterial narrowing. HIV-infected brain donors were more frequently black (80% vs. 15%, P = 0.02) compared with uninfected donors. Inter and intra-reader agreement measures were excellent. The continuous measure of vascular remodeling was significantly higher in the arteries from HIV donors (β = 2.8, P = 0.02). Adjustments for demographics and clinical covariates strengthen this association (β = 9.3, P = 0.01). We found an association of HIV infection with outward brain arterial remodeling. This association might be mediated by a thinner media layer. The reproduction of these results and the implications of this proposed pathophysiology merits further study.
登录
查看更多内容
影响因子：
9.9
作者：
Passero, Stefano G.;Rossi, Simone
通讯作者：
Rossi, Simone
影响因子：
2.9
作者：
Kwon, Hyung-Min;Kim, Ji-Hoon;Lee, Yong-Seok
通讯作者：
Lee, Yong-Seok
影响因子：
37.8
作者：
Hsue, PY;Lo, JC;Waters, DD
通讯作者：
Waters, DD
影响因子：
3.3
作者：
Chetty, R;Batitang, S;Nair, R
通讯作者：
Nair, R
影响因子：
8.3
作者：
Nakatomi, H;Segawa, H;Kirino, T
通讯作者：
Kirino, T