Pre-cachexia in patients with stages I-III non-small cell lung cancer: Systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
Pre-cachexia in patients with stages I-III non-small cell lung cancer: Systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
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DOI：
10.1016/j.lungcan.2011.09.012
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发表时间：
2012-04-01
期刊：
影响因子：
5.3
通讯作者：
Schols, A. M.
中科院分区：
文献类型：
--
作者：
den Kamp, C. M. Op;Langen, R. C.;Schols, A. M.
恶病质是非小细胞肺癌（NSCLC）的一种普遍现象，导致死亡率增加和身体机能恶化。临床前研究表明，全身炎症通过肌肉核因子 kappa B (NF-kappa B) 信号传导和随后的泛素蛋白酶体系统 (UPS) 介导的蛋白水解作用，诱发恶病质相关的肌肉萎缩。由于这些通路可能成为早期干预策略的目标，因此需要阐明这些通路的激活增加是否已经存在于早期 NSCLC 恶病质中。因此，本研究的目的是评估 NSCLC 恶病质前期患者的肌肉 NF-κ B 和 UPS 激活。 16 名新诊断的 I-III 期 NSCLC 患者患有
Cachexia is a prevalent phenomenon of non-small cell lung cancer (NSCLC) which is responsible for increased mortality and deterioration of physical performance. Preclinical research indicates that systemic inflammation induces cachexia-related muscle wasting through muscular Nuclear Factor-kappa B (NF-kappa B) signaling and subsequent ubiquitin proteasome system (UPS)-mediated proteolysis. As these pathways could be a target for early intervention strategies, it needs to be elucidated whether increased activation of these pathways is already present in early stage NSCLC cachexia. The aim of the present study was therefore to assess muscular NF-kappa B and UPS activation in patients with NSCLC pre-cachexia. Sixteen patients with newly diagnosed stages I-Ill NSCLC having