TYPE-II COLLAGEN-INDUCED ARTHRITIS IN MICE .2. PASSIVE TRANSFER AND SUPPRESSION BY INTRAVENOUS-INJECTION OF ANTI-TYPE-II COLLAGEN ANTIBODY OR FREE NATIVE TYPE-II COLLAGEN
TYPE-II COLLAGEN-INDUCED ARTHRITIS IN MICE .2. PASSIVE TRANSFER AND SUPPRESSION BY INTRAVENOUS-INJECTION OF ANTI-TYPE-II COLLAGEN ANTIBODY OR FREE NATIVE TYPE-II COLLAGEN
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DOI：
10.1002/art.1780270907
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
DAVID, CS
中科院分区：
文献类型：
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作者：
WOOLEY, PH;LUTHRA, HS;DAVID, CS
从患有 II 型胶原诱导性关节炎的小鼠中被动转移高水平的抗 II 型胶原抗体可能会将关节炎转移到同系受体动物身上。然而，转移致关节炎或亚致关节炎剂量的多克隆抗II型胶原抗体，或非致关节炎单克隆抗II型胶原抗体，可以保护小鼠免受随后由II型胶原诱导的关节炎。在静脉注射游离天然 II 型胶原蛋白的小鼠中也观察到了保护作用。在关节炎方案中施用胶原蛋白之前。
The passive transfer of high levels of anti-type II collagen antibody from mice with type II collagen-induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub-arthritogenic doses of polyclonal anti-type II collagen antibody, or non-arthritogenic monoclonal anti-type II collagen antibody, may protect mice against the subsequent induction of arthritis by type II collagen. A protective effect was also observed in mice given free native type II collagen i.v. before the administration of collagen in an arthritogenic protocol.