Association of Androgens and Gonadotropins with Amnestic Mild Cognitive Impairment and Probable Alzheimer's Disease in Chinese Elderly Men
Association of Androgens and Gonadotropins with Amnestic Mild Cognitive Impairment and Probable Alzheimer's Disease in Chinese Elderly Men
复制标题
雄激素和促性腺激素与中国老年男性遗忘性轻度认知障碍和可能的阿尔茨海默病的关系
DOI：
10.3233/jad-200233
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发表时间：
2020-01-01
影响因子：
4
通讯作者：
Cui, Huixian
中科院分区：
文献类型：
--
作者：
Li, Yan;Li, Sha;Cui, Huixian
背景：年龄相关激素变化在老年男性认知功能减退中起重要作用，载脂蛋白E epsilon 4(ApoE Epsilon 4)是阿尔茨海默病(AD)的危险因素。目的：本研究旨在探讨雄激素下降与apoE epsilon 4基因在遗忘性轻度认知功能障碍(amememitic轻度认知损害，aMCI)和AD发病机制中的交互作用。认知功能通过一系列神经心理测试进行评估。结果：aMCI组游离睾酮(FT)和双氢睾酮(Dht)水平低于正常对照组(p<；0.001)，AD组更低(p<；0.01)，而促卵泡刺激素(FSH)和黄体生成素(LH)水平高于正常对照组和aMCI组。低FT或DHT水平与APOE epsilon 4的相互作用在整体认知损害中起危险作用(p<；0.05)。根据血清FT水平预测aMCI的ROC曲线下面积(AUC)为0.745。结论：雄激素水平下降与APOE epsilon 4基因的交互作用在aMCI和AD发病中起一定作用。血清FT水平对aMCI有预测价值，并可能成为先兆AD的潜在生物标志物。
Background: Age-related hormone changes play important roles in cognitive decline in older men, and apolipoprotein E epsilon 4 (APOE epsilon 4) is a risk factor for Alzheimer's disease (AD).Objective: This study aimed to investigate the interactive role of androgen decline and APOE epsilon 4 genotype in the pathogenesis of amnestic mild cognitive impairment (aMCI) and AD.Methods: In total, 576 elderly men over 65 years old from communities in Shijiazhuang were enrolled in this study, including 243 with normal cognition (NC), 271 with aMCI, and 62 with probable AD. Cognitive functionwas evaluated with a battery of neuropsychological tests. The serum levels of androgen and gonadotropin were detected by ELISA and chemiluminescence immunoassay.Results: The levels of free testosterone (FT) and dihydrotestosterone (DHT) were lower in the aMCI group (p < 0.05), and even lower in the AD group (p < 0.001), but the levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were higher in AD group (p < 0.01), comparing with that in NC or aMCI group. The interaction of lower FT or DHT levels with APOE epsilon 4 had a risk role in global cognitive impairment (p < 0.05). The area under the curve (AUC) of the ROC curve for predicting aMCI by serum FT levels was 0.745.Conclusion: These results indicated that the interaction of androgen decline and APOE epsilon 4 genotype play a role in aMCI and AD. Serum FT levels have a predictive value for aMCI and might be a potential biomarker for prodromal AD.