Concordant restoration of ovarian function and mood in perimenopausal depression
Concordant restoration of ovarian function and mood in perimenopausal depression
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DOI：
10.1176/appi.ajp.160.10.1842
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发表时间：
2003-10-01
影响因子：
17.7
通讯作者：
Schmidt, PJ
中科院分区：
文献类型：
--
作者：
Daly, RC;Danaceau, MA;Schmidt, PJ
目的：尽管有报道雌激素对围绝经期抑郁症的疗效，但围绝经期抑郁症患者的卵巢功能与情绪之间的关系尚不清楚。本研究的目的是观察围绝经期抑郁症患者的情绪和垂体-卵巢轴功能的变化。方法：在基线和6周的筛查期后，对110名到更年期门诊就诊的绝经后抑郁症妇女(N=110)进行抑郁评分(来自流行病学研究中心抑郁量表[CES-D量表])和血浆卵泡刺激素(FSH)水平。结果：18名妇女在6周时抑郁症状得到改善(CES-D量表评分下降50%)，同时FSH水平显著下降(基线：平均值=73.3IU/L[SD=42.0]；第6周：平均值=42.2IU/升[SD=28.6])。同样，那些血浆FSH水平下降50%的受试者CES-D量表得分显著降低(基线：平均值=23.3[SD6.8]；第6周：平均值=18.1[SD=10.9])。然而，CES-D量表得分大于或等于15的女性与CES-D量表得分的女性之间存在差异
Objective: Despite reports of estradiol's therapeutic efficacy in perimenopausal depression, the relationship between ovarian function and mood in perimenopausal depression remains unclear. The purpose of this study was to examine changes in mood and pituitary-ovarian axis function in women exhibiting perimenopausal depression.Method: Depression ratings (from the Center for Epidemiologic Studies-Depression Scale [CES-D Scale]) and follicle-stimulating hormone (FSH) plasma levels of depressed perimenopausal women (N=110) attending a menopause clinic were obtained at baseline and after a 6-week screening period.Results: Eighteen women experienced an improvement in depression (50% decline in CES-D Scale scores) at week 6, which was associated with a significant decrease in FSH plasma levels (baseline: mean=73.3 IU/liter [SD=42.0]; week 6: mean=42.2 IU/ liter [SD=28.6]). Similarly, those subjects experiencing a 50% drop in FSH plasma levels had significant decreases in CES-D Scale scores (baseline: mean=23.3 [SD6.8]; week 6: mean=18.1 [SD=10.9]). However, between women with CES-D Scale scores greater than or equal to15 and those with CES-D Scale scores