Elimination of toluene from venous blood and adipose tissue after occupational exposure.
Elimination of toluene from venous blood and adipose tissue after occupational exposure.
复制标题
消除职业接触后静脉血和脂肪组织中的甲苯。
DOI：
10.1136/oem.46.6.407
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Palle Örbaek
中科院分区：
文献类型：
--
作者：
G. Nise;R. Attewell;S. Skerfving;Palle Örbaek
在一组37个轮转凹版印刷机之间的密切相关性（rs = 0.78），发现在一个五天的工作周（范围8-416 mg/m3，中位数75）和皮下脂肪组织中的甲苯浓度（范围1.1-20.7 mg/kg，中位数3.8）的时间加权甲苯暴露。在暴露停止后，对11名受试者的甲苯消除情况进行了随访。静脉血中甲苯浓度呈非线性下降，消除曲线至少包含三个指数分量。前两次的中场休息时间分别为9分钟和2小时。第三个组成部分的中位半衰期为90小时，反映了脂肪组织的减少，其中位半衰期为79小时（范围44-178）。研究表明，外源性暴露结束后很长时间内，脂肪组织库的内源性甲苯暴露。观察结果还表明，周一早晨的血液甲苯浓度可作为前一周暴露的指标。
In a group of 37 rotogravure printers a close correlation (rs = 0.78) was found between the time weighted toluene exposure during a five day working week (range 8-416 mg/m3, median 75) and the concentration of toluene in subcutaneous adipose tissue (range 1.1-20.7 mg/kg, median 3.8). After exposure ceased, the elimination of toluene was followed up in 11 subjects. The toluene concentration in venous blood decreased non-linearly and the elimination curves contained at least three exponential components. The first two had median estimated half times of nine minutes and two hours respectively. The third component, with a median half time of 90 hours, reflected the decline in adipose tissue, which had a median half time of 79 hours (range 44-178). The study showed protracted endogenous toluene exposure from adipose tissue depots long after the end of exogenous exposure. The observations also suggest that the blood toluene concentrations on Monday mornings might be used as an index of the exposure in the previous week.